28319-72-4

Basic information

• Product Name: ANDROSTA-3,5,9(11)-TRIEN-17-ONE, 3-METHOXY
• Synonyms: ANDROSTA-3,5,9(11)-TRIEN-17-ONE, 3-METHOXY
• CAS NO: 28319-72-4
• Molecular Formula: C₂₀H₂₆O₂
• Molecular Weight: 298.42
• Mol File: 28319-72-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ANDROSTA-3,5,9(11)-TRIEN-17-ONE, 3-METHOXY(CAS DataBase Reference)
• NIST Chemistry Reference: ANDROSTA-3,5,9(11)-TRIEN-17-ONE, 3-METHOXY(28319-72-4)
• EPA Substance Registry System: ANDROSTA-3,5,9(11)-TRIEN-17-ONE, 3-METHOXY(28319-72-4)

Safety Data

• Hazardous Substances Data: 28319-72-4(Hazardous Substances Data)

Upstream product

• 1035-69-4 androst-4,9⁽¹¹⁾-dien-3,17-dione 
• 149-73-5 trimethyl orthoformate 
• 1035-69-4 Androstadien-(4,9,⁽¹¹⁾)-dion-3,17 

Downstream Products

• 93206-68-9 (E)-17-(isocyanotosylmethylene)-3-methoxyandrosta-3,5,9⁽¹¹⁾-triene 
• 95716-71-5 Δ⁹⁽¹¹⁾-canrenone 

Relevant articles and documents

Efficient preparation method of delta-canrenone

The invention discloses an efficient preparation method of delta-canrenone, and belongs to the technical field of preparation of intermediates of medicines. The method comprises the following steps of: by taking 9 alpha-hydroxyl-4-androstenedione as a raw material, firstly removing 9-site hydroxyl through dehydration reaction to generate delta double bonds, then protecting 3-site carbonyl, then performing epoxidation on 17-site carbonyl, condensing with malonic acid diester to form a lactone ring, and performing oxidative decarboxylation or decarboxylation oxidation reaction to obtain delta-canrenone. According to the method, the raw materials are cheap and easy to obtain, the cost is low, reaction products in all steps are easy to purify, the total mass yield of the final product is higher than 80%, and the method is high in operability, extremely high in commercial competitiveness, suitable for industrial large-scale production and good in economic benefit.

A 16 ɑ-methyl steroids method for the preparation of (by machine translation)

The invention discloses a 16 ɑ? The preparation method of compound methyl steroid race, with compound I as the starting material, through a protection reaction, nucleophilic substitution reaction, hydrolytic reaction, the 3-bit and 16 bit transformation, VI the final product is prepared. This invention uses the new starting material, the reaction step is short, on the 16 ɑ methyl steps a position which is in front of the whole product, the great convenience to have 16 ɑ methyl steroid drugs new circuit design, the follow-up all-step reaction is relatively easy to realize, high yield, which makes the production more economic, safety, more suitable for industrial production; the invention changes the existing in the industry on the format used by the reaction of methyl 16 ɑ, changes the configuration of the poor selectivity, a side reaction, and the need for a plurality of position and protect the status quo, contribute greatly to the industry the technical progress; this invention adopts the nucleophilic substituted substantially avoid the generation of the configuration isomers, almost no side reaction, greatly improving the yield, the cost is reduced. (by machine translation)

17 α-chloroethynyl pregnane derivatives

Known pregnane derivatives are prepared by esterificiation of known androstane derivatives to give new ester of Formula III STR1 wherein in each case symbolizes a single bond or a double bond, n is 1 or 2, R1 is hydrogen or methyl, R2 is hydrogen or formyl, and R3 is chlorine, hydroxy or an alkanoyloxy group of up to 6 carbon atoms, and reaction of the latter with Ag(I) and formic acid.