28321-10-0

Basic information

• Product Name: 1-(2,2-difluorovinyl)-2-methylbenzene
• Synonyms: 1-(2,2-difluorovinyl)-2-methylbenzene
• CAS NO: 28321-10-0
• Molecular Weight: 154.159
• Mol File: 28321-10-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(2,2-difluorovinyl)-2-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-difluorovinyl)-2-methylbenzene(28321-10-0)
• EPA Substance Registry System: 1-(2,2-difluorovinyl)-2-methylbenzene(28321-10-0)

Safety Data

• Hazardous Substances Data: 28321-10-0(Hazardous Substances Data)

Upstream product

• 1895-39-2 sodium chlorodifluoroacetate 
• 529-20-4 2-methylphenyl aldehyde 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 16419-60-6 2-Methylphenylboronic acid 
• 615-37-2 ortho-methylphenyl iodide 
• 2925-16-8 1,1-difluoro-2-iodoethylene 

Downstream Products

• 28321-17-7 N,N-Diethyl-o-tolylethinylamin 

Relevant articles and documents

Dehalogenative Cross-Coupling of gem-Difluoroalkenes with Alkyl Halides via a Silyl Radical-Mediated Process

Herein, we describe a convenient general protocol for monofluoroalkenylation reactions of alkyl bromides involving cooperative visible-light photoredox catalysis and halogen abstraction. Mechanistic experiments showed that the products were generated by selective cross-coupling of aliphatic radicals with fluoroalkenyl radicals. Silyl radical-mediated halogen abstraction enabled the protocol to be used for the monofluoroalkenylation of a broad range of alkyl and heteroaryl halides. The protocol could be carried out on a gram scale and was applied to cholesterol, indicating its utility for late-stage monofluoroalkenylation reactions.

Switchable 2,2,2-trifluoroethylation and gem-difluorovinylation of organoboronic acids with 2,2,2-trifluorodiazoethane

The transition-metal-free 2,2,2-trifluoroethylation and gem-difluorovinylation of arylboronic acids were developed. By employing different reaction conditions, these transformations provide both (2,2,2-trifluoroethyl)arenes and gem-difluorovinylarenes fro

A New Route for the Preparation of Substituted 2,2-Difluorostyrenes and a Convenient Route to Substituted (2,2,2-Trifluoroethyl)benzenes

The (2,2-difluoroethenyl)zinc reagent II is coupled with aryl iodides or bromides in the presence of Pd(PPh3)4 in DMF to give the corresponding 2,2-difluorostyrenes IV. The 4-substituted (tetrafluoroaryl)copper reagents are coupled with 2,2-difluoro-1-iodoethylene (I) to produce the corresponding styrene derivatives VII. Both methods provide good yields of the coupled products. These products react with wet KF in DMF or DMSO to form the (2,2,2-trifluoroethyl)benzene derivatives VIII in good yields.