28322-03-4Relevant academic research and scientific papers
Efficient palladium-catalyzed C(sp2)-H activation towards the synthesis of fluorenes
Song, Juan,Li, Yali,Sun, Wei,Yi, Chenglong,Wu, Hao,Wang, Haotian,Ding, Keran,Xiao, Kang,Liu, Chao
, p. 9030 - 9033 (2016/11/11)
A facile protocol for the synthesis of fluorene derivatives has been developed through palladium-catalyzed cyclization of 2′-halo-diarylmethanes via activation of arylic C-H bonds. The reactions occurred smoothly and allowed both electron-rich and electron-deficient substrates to convert into their corresponding fluorenes in good to excellent yields. Studies revealed that this Pd-catalyzed cyclization was also available for the substrates of 2′-chloro-diarylmethanes and no catalyst poisoning occurred for 2′-iodo-diphenylmethane.
