28345-77-9

Upstream product

• 55596-51-5 2-Benzyloxycarbonylamino-4-hydroxy-butyric acid 4-nitro-benzyl ester 
• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 55596-52-6 (S)-2-Benzyloxycarbonylamino-4-(diphenoxy-phosphoryloxy)-butyric acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

Synthesis of (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers: Probes for the pyridoxal phosphate-dependent threonine synthase reaction

A short efficient synthesis of the threonine synthase substrate (2S)-O-phosphohomoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers is described. The synthetic route also provides access to (2S)-homoserine and its C-2 deuteriated and C-3 chirally deuteriated isotopomers in high yield. Preliminary deuterium isotope effect determinations performed using the deuteriated (2S)-O-phosphohomoserines and threonine synthase from E. coli indicate that the removal of protons from both C-2 and C-3 is kinetically important.

Synthesis of L-O-Phosphohomoserine and its C-3 Chirally Deuteriated Isotopomers: Probes for the Pyridoxal Phosphate Dependent Threonine Synthase Reaction

A short efficient synthesis of the threonine synthase substrate L-O-phosphohomoserine and its C-3 chirally deuteriated isotopomers is described; the route also provides access to L-homoserine and its C-3 chirally deuteriated isotopomers in high yield.