28354-22-5

Basic information

• Product Name: m-Toluidinoacetonitrile
• Synonyms: m-Toluidinoacetonitrile
• CAS NO: 28354-22-5
• Molecular Formula: C₉H₁₀N₂
• Molecular Weight: 146.1891
• Mol File: 28354-22-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 316.9°Cat760mmHg
• Flash Point: 145.5°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 0.000398mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: m-Toluidinoacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: m-Toluidinoacetonitrile(28354-22-5)
• EPA Substance Registry System: m-Toluidinoacetonitrile(28354-22-5)

Safety Data

• Hazardous Substances Data: 28354-22-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H10N2/c1-8-3-2-4-9(7-8)11-6-5-10/h2-4,7,11H,6H2,1H3

Upstream product

• 372-09-8 cyanoacetic acid 
• 108-44-1 1-amino-3-methylbenzene 

Downstream Products

• 749156-18-1 2-(3-Methylanilino)-acetamidoxime dihydrochloride 
• 93192-51-9 N-Nitroso-N-<3-methyl-phenylamino>-acetonitril 

Relevant articles and documents

Cyanoacetic Acid as a Masked Electrophile: Transition-Metal-Free Cyanomethylation of Amines and Carboxylic Acids

Using cyanoacetic acid as a masked electrophile, a new cyanomethylation reaction of amines and carboxylic acids was developed, producing a variety of α-aminonitriles and cyanomethyl esters with good yields and excellent functionality tolerance. This protocol features simple manipulation, inexpensive reagents, and a wide substrate scope. Iodoacetonitrile was generated in situ from the iodination-decarboxylation of cyanoacetic acid in this transformation.