283598-20-9

Basic information

• Product Name: (1'R,2'R,3'S)-9-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}adenine
• Synonyms: (1'R,2'R,3'S)-9-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}adenine
• CAS NO: 283598-20-9
• Molecular Weight: 551.645
• Mol File: 283598-20-9.mol

Chemical Properties

• CAS DataBase Reference: (1'R,2'R,3'S)-9-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}adenine(CAS DataBase Reference)
• NIST Chemistry Reference: (1'R,2'R,3'S)-9-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}adenine(283598-20-9)
• EPA Substance Registry System: (1'R,2'R,3'S)-9-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}adenine(283598-20-9)

Safety Data

• Hazardous Substances Data: 283598-20-9(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 207344-94-3 (1'R,2'R,3'S)-9-[2'-benzoyloxymethyl-3'-hydroxymethylcyclobutyl]adenine 
• 132294-20-3 (1'S,2'S,3'R)-9-[2',3'-bis(benzoyloxymethyl)cyclobutyl]adenine 

Relevant articles and documents

Artificial oligonucleotides consisting of an analog of nucleoside antibiotics, carbocyclic oxetanocins1

Modified oligonucleotides, hexadecamers, containing carbocyclic analogues of oxetanocin A and T, have been synthesized from the corresponding chiral carbocyclic nucleosides. The oligonucleotide derived from carbocyclic oxetanocin A forms a stable triple-helix with uridine oligoribonucleotide even under physiological conditions.

Synthesis and hybridization property of oligonucleotides containing carbocyclic oxetanocins

Oligonucleotides containing enantiomeric carbocyclic oxetanocins possessing adenine, thymine, guanine and cytosine were synthesized from an optically active cyclobutane derivative. Their hybridization properties with the complementary oligonucleotides were studied using melting point method, CD spectroscopy, and mixing curve method (Job plots). The artificial nucleotides possessing adenine, guanine and cytosine bases show tendency to form complexes more strongly with ribonucleotide than deoxyribonucleotide. These complexes are triplexes consisting of purine and pyrimidine in 1:2 ratio. Such triplex formation is observed both under high (1 M NaCl) and low salt conditions (0.1 M NaCl). (C) 2000 Elsevier Science Ltd.