28361-43-5

Usage

Uses

Used in Polymer and Resin Production:
1,1'-Sulfonylbis(3,4-dimethylbenzene) is used as a cross-linking agent for enhancing the stability and durability of polymers and resins. Its ability to form covalent bonds between polymer chains contributes to the improved mechanical properties and chemical resistance of the final products.
Used in Dye and Pigment Synthesis:
In the dye and pigment industry, 1,1'-Sulfonylbis(3,4-dimethylbenzene) serves as a crucial raw material. Its chemical structure allows for the creation of a wide range of colors and shades, making it an essential component in the production of various dyes and pigments for different applications.
Used in Pharmaceutical Manufacturing:
1,1'-Sulfonylbis(3,4-dimethylbenzene) plays a significant role in the pharmaceutical industry, where it is utilized in the synthesis of various drugs. Its unique chemical properties enable the development of new pharmaceutical compounds with potential therapeutic benefits.
Used as an Industrial Chemical Intermediate:
1,1'-Sulfonylbis(3,4-dimethylbenzene) is also employed as an intermediate in the manufacturing of a variety of industrial chemicals. Its versatility and reactivity make it a valuable component in the production of different chemical products used in various applications.
Safety Precautions:
It is important to handle 1,1'-Sulfonylbis(3,4-dimethylbenzene) with care, as it can cause irritation to the skin, eyes, and respiratory system. Additionally, it may have harmful effects if ingested or inhaled. Proper safety measures, such as wearing protective gear and ensuring proper ventilation, should be taken during its use and handling.

InChI:InChI=1/C16H18O2S/c1-11-5-7-15(9-13(11)3)19(17,18)16-8-6-12(2)14(4)10-16/h5-10H,1-4H3

Upstream product

• 95-47-6 o-xylene 
• 2905-30-8 3,4-dimethylbenzenesulfonyl chloride 
• 1343-93-7 phosphotungestic acid 
• 80-48-8 methyl p-toluene sulfonate 
• 15481-45-5 methyl p-chlorobenzenesulphonate 

Relevant academic research and scientific papers

Facile synthesis of diarylsulfones from arenes and 3CdSO4·xH2O via mechanochemistry

A variety of substituted diarylsulfones could be synthesized by simple arenes and 3CdSO4·xH2O in the presence of P2O5 under high-speed ball milling. It was suggest the aromatic sulfonation was performed by arene and in situ generated H2SO4, following-up by electrophilic substitution with another arene to give diarylsulfone.

The synthesis of diarylsulfones with simple arenes and K2S2O8 through double C-S bond formation

An unprecedented double C-S bond formation method has been developed to prepare both symmetric and unsymmetric diarylsulfones with simple arenes in a single step. This represents the first example that K2S2O8 can be employed as a highly effective sulfonating agent to synthesize diarylsulfones. The reaction demonstrates excellent reactivity, good functional group tolerance and high yields.

Synthesis of symmetric diaryl sulfones with dimethyl sulfate

In this procedure dimethyl sulfate was used for preparation of symmetric diaryl sulfones. First, dimethyl sulfate was treated with pyridine, then activated by Tf2O to generate SO2 as the functional group for synthesis of diaryl sulfones. It is noticeable that this reaction was carried out in moderate conditions and products obtained in short times and good yields.

Process for preparing diarylsulfones

In preparing a diarylsulfone by condensing sulfuric acid or an aromatic sulfonic acid with an aromatic compound having at least one replaceable hydrogen atom on the aromatic ring, the process of the present invention is characterized in that the condensation reaction is carried out in the presence of at least one catalyst selected from the group consisting of a tungstic acid, molybdic acid and heteropoly acid thereof.

REACTION OF ALKYL ARENESULFONATES WITH LIQUID SULFUR TRIOXIDE AND AROMATIC HYDROCARBONS

The reaction of sulfur trioxide with methyl 4-toluenesulfonate leads to the formation of p-CH3C6H4SO2(OSO2)nOCH3 (n=1,2) compounds.Investigation of the composition of the products from the reaction of this mixture with aromatic hydrocarbons showed that the diaryl sulfones in this case are formed by a pyrosulfonate mechanism.The optimum conditions for the synthesis of diaryl sulfones were selected.

Sulfosilylation of Aromatic Hydrocarbons by Trimethylsilyl Chlorosulfonate

Aromatic hydrocarbons 2 ,6 ,8 ,9 ,13 ,16 ,18 ,19 ,22 react with trimethylsilyl chlorosulfonate (1) to give trimethylsilyl arenesulfonates 5, 7, 11, 12, 15, 23 or sulfonic acids 17, 20, 21.If trimethylsilyl sulfonates are obtained, working up of the sulfonation mixtures is possible by distillation.By hydrohalogenolysis of trimethylsilyl sulfonates 5 at 0-5 deg C anhydrous sulfonic acids 3 result.The pathways to diphenylsulfone (25a) in the reaction of benzene (2a) with 1 were investigated.In this connection we succeeded in synthesizing benzenepyrosulfonic acid (28) and trimethylsilyl benzenepyrosulfonate (29).

METHODS FOR THE SYNTHESIS OF 3,4-DIMETHYLPHENYL 4'-CHLOROPHENYL SULFONE

A method was developed for the preparative synthesis of 3,4-dimethylphenyl 4'-chlorophenyl sulfone by sulfonylation of o-xylene and chlorobenzene with 4-chlorobenzene- and 3,4-dimethylbenzenesulfonyl chlorides respectively in the presence of ferric chloride as catalyst.The desired compound was also obtained with an 80 mole percent yield by the reaction of methyl 3,4-dimethylbenzenesulfonate with liquid sulfur trioxide.The main intermediate products in this synthesis are compounds of the RC6H4SO2O.(SO2O)nCH3, where n = O, 1, 2.