2837-61-8 Usage
General Description
The chemical compound "2,2-dichloro-N-[3-(trifluoromethyl)phenyl]acetamide" is an organic compound with the molecular formula C10H7Cl2F3NO. It is a derivative of acetamide, containing two chlorine atoms and a trifluoromethylphenyl group attached to the nitrogen atom. 2,2-dichloro-N-[3-(trifluoromethyl)phenyl]acetamide is mainly used as a herbicide and pesticide, with its mode of action involving inhibition of photosystem II in plants, leading to their death. It is considered to be a broad-spectrum herbicide, effective against a wide range of weed species. The compound is stable under normal conditions and is primarily applied as a liquid spray to target plant foliage. Due to its potential environmental and health hazards, its use is subject to regulatory control in many countries.
Check Digit Verification of cas no
The CAS Registry Mumber 2837-61-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,3 and 7 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2837-61:
(6*2)+(5*8)+(4*3)+(3*7)+(2*6)+(1*1)=98
98 % 10 = 8
So 2837-61-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H6Cl2F3NO/c10-7(11)8(16)15-6-3-1-2-5(4-6)9(12,13)14/h1-4,7H,(H,15,16)
2837-61-8Relevant articles and documents
Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: Design, synthesis and biological evaluation
Yang, Yongchong,Shang, Peihua,Cheng, Changmei,Wang, Dongchun,Yang, Ping,Zhang, Feng,Li, Tianwen,Lu, Aijun,Zhao, Yufen
experimental part, p. 4300 - 4306 (2010/10/02)
A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC50 > 1000 μM for A549). In this paper, a variety of DCA derivatives were synthesized, and their cytotoxic activities were evaluated. The result showed that the N-phenyl-2,2-dichloroacetamide analogues had satisfactory potencies. Among them, N-(3-iodophenyl)-2,2-dichloroacetamide (3e), an optimized lead compound, has an IC50 against A549 as low as 4.76 μM. Furthermore, it can induce cancer cell apoptosis and has a low toxicity in mice (LD50 = 1117 mg/kg). N-phenyl-2,2-dichloroacetamide analogues has higher cytotoxic activity and N-(3-iodophenyl)-2,2-dichloroacetamide (3e) is an optimized lead compound.
