28371-10-0

Basic information

• Product Name: quinidine polygalacturonate
• Synonyms: quinidine polygalacturonate;2-Quinuclidinemethanol, alpha-(6-methoxy-4-quinolyl)-5-vinyl-, galacturonate (salt);Galactoquin;Galacturonic acid, compd. with (9S)-6'-methoxycinchonan-9-ol (1:1) (9ci);Galacturonic acid, compd. with alpha-(6-methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol;Galacturonic acid, compd. with quinidine
• CAS NO: 28371-10-0
• Molecular Weight: 0
• Mol File: 28371-10-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: quinidine polygalacturonate(CAS DataBase Reference)
• NIST Chemistry Reference: quinidine polygalacturonate(28371-10-0)
• EPA Substance Registry System: quinidine polygalacturonate(28371-10-0)

Safety Data

• Hazardous Substances Data: 28371-10-0(Hazardous Substances Data)

Usage

Description

Quinidine polygalacturonate, also known as Cardioquin, is a compound formed by the reaction of quinidine and polygalacturonic acid in a hydroalcoholic medium. It contains approximately 60% quinidine by equivalence. This salt is slightly ionized and has low solubility in water. Studies have shown that while equivalent doses of quinidine sulfate result in higher peak blood levels earlier, the polygalacturonate salt provides a more uniform and sustained blood level.

Uses

Used in Pharmaceutical Industry:
Quinidine polygalacturonate is used as an active pharmaceutical ingredient for the treatment of various cardiac arrhythmias. Its unique properties, such as slightly ionized and low solubility in water, contribute to a more uniform and sustained blood level compared to quinidine sulfate, making it a preferred choice in certain therapeutic applications.
Used in Drug Delivery Systems:
In the field of drug delivery, quinidine polygalacturonate is utilized as a component in the development of novel drug delivery systems. Its properties can be leveraged to improve the release profile and bioavailability of other drugs, potentially enhancing their therapeutic effects and reducing side effects.
Used in Research and Development:
Quinidine polygalacturonate is also used in research and development for studying the effects of ionization and solubility on drug absorption and distribution. This knowledge can be applied to the design of new drugs and drug formulations, leading to improved efficacy and safety profiles.

Clinical Use

In many patients, the local irritant action of quinidinesulfate in the gastrointestinal tract causes pain, nausea, vomiting,and especially diarrhea, often precluding oral use inadequate doses. Studies with the polygalacturonate saltyielded no evidence of gastrointestinal distress. It is availableas 275-mg tablets. Each tablet is the equivalent of200 mg of quinidine sulfate or 166 mg of free alkaloid.