28373-55-9Relevant academic research and scientific papers
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase
Tipparaju, Suresh K.,Joyasawal, Sipak,Forrester, Sara,Mulhearn, Debbie C.,Pegan, Scott,Johnson, Michael E.,Mesecar, Andrew D.,Kozikowski, Alan P.
supporting information; experimental part, p. 3565 - 3569 (2009/04/10)
Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.
