28395-45-1Relevant academic research and scientific papers
When inhibitors do not inhibit: Critical evaluation of rational drug design targeting chorismate mutase from mycobacterium tuberculosis
Munack, Steffi,Leroux, Vincent,Roderer, Kathrin,?kvist, Mats,Van Eerde, André,Gundersen, Lise-Lotte,Krengel, Ute,Kast, Peter
, p. 2507 - 2527 (2013/01/16)
Tuberculosis (TB) is a devastating disease that claims millions of lives every year. Hindered access or non-compliance to medication, especially in developing countries, led to drug resistance, further aggravating the situation. With current standard ther
3-Amino, 4-thio-substituted, 5-sulphamyl-benzoic acid derivatives
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, (2008/06/13)
This invention relates to new, therapeutically active compounds of the general formula SPC1 In which A represents one of the groupings EQU1 R2 --O--, R2 --S--, R2 --OS--, and R2 --O2 S--, R1, R2, R3, and R4 each represents hydrogen, an aliphatic radical, a cycloaliphatic radical, or an aromatically, cycloaliphatically, or heterocyclically substituted aliphatic radical, in addition to which R2 and R3 may each represent an aromatic or heterocyclic radical, and when A is EQU2 R1 and R2 may be linked to form a 5- to 8-membered heterocyclic ring system, which may have one or more nitrogen atoms, sulphur atoms, or oxygen atoms in addition to the nitrogen atom linked to R1 and R2 ; R5 is hydrogen or lower alkyl; and R6 is hydrogen or lower alkyl or acyl; to salts, esters, and amides of the said compounds; and to methods for the production of the compounds.
