28398-76-7Relevant articles and documents
Synthesis and acetylcholinesterase inhibitory activity of polyhydroxylated sulfated steroids: Structure/activity studies
Richmond, Victoria,Murray, Ana P.,Maier, Marta S.
, p. 1141 - 1147 (2013)
Disulfated and trisulfated steroids have been synthesized from cholesterol and their acetylcholinesterase inhibitory activity has been evaluated. In our studies we have found that the activity was not only dependent on the location of the sulfate groups but on their configurations. 2β,3α,6α- trihydroxy-5α-cholestan-6-one trisulfate (18) was the most active steroid with an IC50 value of 15.48 μM comparable to that of 2β,3α-dihydroxy-5α-cholestan-6-one disulfate (1). Both compounds were found to be less active than the reference compound eserine. The butyrylcholinesterase activity of 1 and 18 was one magnitude lower than that against acetylcholinesterase revealing a selective inhibitor profile.
Potassium Borohydride Reductions of Ketones absorbed into Polymer Supports: Stereochemical Effects
Briggs, Josie C.,Hodge, Philip
, p. 310 - 311 (2007/10/02)
The proportions of 6α-alcohol obtained from aqueous potassium borohydride reductions of 3β-cholestan-6-one (1) absorbed into various polymers varied from 0 to 90percent depending on the polymer used and whether or not a phase transfer catalyst was added; some other ketones show similar streochemical effects, the greatest effects probably arising when the substrates are adsorbed to the inner surfaces of appropriate polymers.
