284032-16-2Relevant academic research and scientific papers
2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)
Warmus, Joseph S.,Flamme, Cathlin,Zhang, Lu Yan,Barrett, Stephen,Bridges, Alexander,Chen, Huifen,Gowan, Richard,Kaufman, Michael,Sebolt-Leopold, Judy,Leopold, Wilbur,Merriman, Ronald,Ohren, Jeffrey,Pavlovsky, Alexander,Przybranowski, Sally,Tecle, Haile,Valik, Heather,Whitehead, Christopher,Zhang, Erli
scheme or table, p. 6171 - 6174 (2009/07/18)
This paper reports a second generation MEK inhibitor. The previously reported potent and efficacious MEK inhibitor, PD-184352 (CI-1040), contains an integral hydroxamate moiety. This compound suffered from less than ideal solubility and metabolic stabilit
