284035-38-7

Upstream product

• 284035-53-6 [(2R,4S,5S,6R)-6-(4-Benzyloxy-butyl)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-methanol 
• 78999-24-3 5-benzyloxy-1-pentanal 
• 171189-79-0 (S)-4-Benzyl-3-((2S,3R)-7-benzyloxy-3-hydroxy-2-methyl-heptanoyl)-oxazolidin-2-one 
• 284035-47-8 (2S,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanal 
• 284035-45-6 (2R,3R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptan-1-ol 
• 284035-51-4 Benzoic acid (2R,4S,5R,6R)-6-(4-benzyloxy-butyl)-4-hydroxy-2-methoxy-5-methyl-tetrahydro-pyran-2-ylmethyl ester 
• 284035-52-5 Benzoic acid (2R,4S,5S,6R)-6-(4-benzyloxy-butyl)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-5-methyl-tetrahydro-pyran-2-ylmethyl ester 
• 284035-43-4 (S)-4-Benzyl-3-[(2S,3R)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanoyl]-oxazolidin-2-one 

Relevant academic research and scientific papers

Synthetic studies on spongistatins: Synthesis of the C29-C44 fragment

A convergent synthesis of the C29-C44 fragment, the common subunit of the spongipyran macrolides is described. The key step of the synthesis is the C-glycosidation reaction which is based on coupling of the lithiated F-ring sulfone with the E-ring aldehyde, and subsequent reductive desulfonylation to afford the E-F bis (pyran) with high stereoselectivity at the anomeric carbon. (C) 2000 Elsevier Science Ltd.