28419-69-4

Usage

Physical state

White crystalline solid

Chemical classification

Aromatic compound

Common uses

Intermediate in the manufacture of pesticides, particularly herbicides

Application in research

Used for its chemical properties in laboratory settings

Environmental impact

Potential environmental hazard

Health hazard

Classified as a hazardous substance due to its toxicity

Regulatory status

Subject to regulatory control by agencies

Handling and disposal

Proper handling and disposal methods should be followed to minimize harm to the environment and human health

InChI:InChI=1/C12H8Cl2O/c13-10-7-4-8-11(14)12(10)15-9-5-2-1-3-6-9/h1-8H

Upstream product

• 100-67-4 potassium phenolate 
• 87-61-6 1,2,3-trichlorobenzene 
• 591-50-4 iodobenzene 
• 87-65-0 2,6-Dichlorophenol 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

CoII Immobilized on Aminated Magnetic-Based Metal–Organic Framework: An Efficient Heterogeneous Nanostructured Catalyst for the C–O Cross-Coupling Reaction in Solvent-Free Conditions

Abstract: In this paper, we report the synthesis of Fe3O4?AMCA-MIL53(Al)-NH2-CoII NPs based on the metal–organic framework structures as a magnetically separable and environmentally friendly heterogeneous nanocatalyst. The prepared nanostructured catalyst efficiently promotes the C–O cross-coupling reaction in solvent-free conditions without the need for using toxic solvents and/or expensive palladium catalyst. Graphic Abstract: [Figure not available: see fulltext.].

Copper-mediated synthesis of mono- and dichlorinated diaryl ethers

An efficient synthesis of polychlorinated diphenyl ethers (PCDEs) using the Cu(OAc)2-catalyzed Chan-Lam coupling reaction is described. A library of all possible mono- and dichlorinated diphenyl ether congeners was prepared and characterized using MS, 1H, and 13C NMR spectroscopy, and Kovats retention indices. Our approach, using the optimized reaction conditions (i.e., reaction temperature, oxidizing atmosphere and base), significantly improves and simplifies the process compared to previously reported syntheses.