28442-78-6

Basic information

• Product Name: 2-Chloroisophthalonitrile
• Synonyms: 2-Chloroisophthalonitrile;2,6-DICYANOCHLOROBENZENE ;1-CHLORO-2,6-DICYANOBENZENE;2-CHLORO-1,3-DICYANOBENZENE;2-Chloro-1,3-benzenedicarbonitrile;2-chlorophthalonitrile
• CAS NO: 28442-78-6
• Molecular Formula: C₈H₃ClN₂
• Molecular Weight: 162.57582
• Product Categories: Nitrile
• Mol File: 28442-78-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 154-156 °C
• Boiling Point: 294.4 °C at 760 mmHg
• Flash Point: 135.63 °C
• Appearance: /
• Density: 1.34 g/cm³
• Vapor Pressure: 0.00163mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloroisophthalonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloroisophthalonitrile(28442-78-6)
• EPA Substance Registry System: 2-Chloroisophthalonitrile(28442-78-6)

Safety Data

• Hazardous Substances Data: 28442-78-6(Hazardous Substances Data)

Usage

General Description

2-Chloroisophthalonitrile is a chemical compound with the molecular formula C8H3ClN2. It is a white, crystalline solid that is primarily used as an intermediate in the production of various chemicals, including dyes and pigments. It is also used as a key ingredient in the synthesis of organic compounds and as a chemical intermediate for pharmaceuticals. 2-Chloroisophthalonitrile is known for its high reactivity and is used in a wide range of industrial applications. It is important to handle this compound with care as it can be hazardous to human health and the environment if not properly controlled and managed.

InChI:InChI=1/C8H3ClN2/c9-8-6(4-10)2-1-3-7(8)5-11/h1-3H

Upstream product

• 626-17-5 benzene-1,3-dicarbonitrile 
• 51762-72-2 Benzene-1-nitro-2,6-dicyano 

Downstream Products

• 914250-51-4 2-(2-iodophenoxy)isophthalonitrile 
• 914250-54-7 2-(2,4,6-trimethylphenoxy)isophthalonitrile 
• 914250-56-9 2-(2-tert-butyl-6-methylphenoxy)benzene-1,3-dinitrile 
• 914250-55-8 2-(2,6-diisopropylphenoxy)isophthalonitrile 
• 914250-53-6 2-(2-tert-butylphenoxy)isophthalonitrile 
• 1595319-77-9 9,9'-bis(2,6-dicyanophenyl)-3,3'-bicarbazolyl 
• 914251-05-1 1-[2-(2,6-diisopropylphenoxy)-3-(2'S,4'S,5'R)-(3',4'-dimethyl-5'-phenyloxazolidin-2-yl)phenyl]ethan-1-one 
• 914251-04-0 1-[2-(2,4,6-trimethylphenoxy)-3-(2'S,4'S,5'R)-(3',4'-dimethyl-5'-phenyloxazolidin-2-yl)phenyl]ethan-1-one 
• 914251-03-9 1-[2-(2-tert-butylphenoxy)-3-(2'S,4'S,5'R)-(3',4'-dimethyl-5'-phenyloxazolidin-2-yl)phenyl]ethan-1-one 
• 914251-01-7 1-[2-(2-iodophenoxy)-3-(2'S,4'S,5'R)-(3',4'-dimethyl-5'-phenyloxazolidin-2-yl)phenyl]ethan-1-one 
• 914251-02-8 1-[2-(2-isopropylphenoxy)-3-(2'S,4'S,5'R)-(3',4'-dimethyl-5'-phenyloxazolidin-2-yl)phenyl]ethan-1-one 
• 914250-81-0 2-(2-tert-butylphenoxy)-3-[(hydroxy)(phenyl)methyl]benzaldehyde 

Relevant articles and documents

Three groups good, four groups bad? Atropisomerism in ortho-substituted diaryl ethers

(Chemical Equation Presented) Bring on the substitute: Even outside of macrocyclic structures, such as vancomycin, appropriate substitution can give rise to atropisomerism in diaryl ethers. Stereochemical stability about the Ar-OAr axis at room temperature or above is possible when neither of the rings is symmetrically substituted and when at least one ring carries an ortho tert-butyl group or equivalent.

Directed Ortho Lithiation of Isophthalonitrile. New Methodology for the Synthesis of 1,2,3-Trisubstituted Benzenes

The lithiation of 1,3-dicyanobenzene with lithium diisopropylamide occurs in high yield, regiospecifically at the 2-position, to give aryllithium species stable at temperatures below -90 deg C.