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28444-97-5

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28444-97-5 Usage

General Description

16,17-EPOXY-21-ACETOXYPREGNENOLONE is a chemical compound that belongs to the class of pregnane steroids. It is a derivative of pregnenolone, which is a precursor to various steroid hormones in the body. 16,17-EPOXY-21-ACETOXYPREGNENOLONE has an epoxy group at the 16th and 17th positions, as well as an acetoxy group at the 21st position of the pregnenolone structure. These modifications can alter the biological activity and pharmacological properties of the compound. 16,17-EPOXY-21-ACETOXYPREGNENOLONE may have potential applications in the field of pharmacology and medicinal chemistry for the development of novel steroid-based drugs or as a research tool in studying steroid hormone pathways and functions.

Check Digit Verification of cas no

The CAS Registry Mumber 28444-97-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,4,4 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 28444-97:
(7*2)+(6*8)+(5*4)+(4*4)+(3*4)+(2*9)+(1*7)=135
135 % 10 = 5
So 28444-97-5 is a valid CAS Registry Number.
InChI:InChI=1/C23H32O5/c1-13(24)27-12-19(26)23-20(28-23)11-18-16-5-4-14-10-15(25)6-8-21(14,2)17(16)7-9-22(18,23)3/h4,15-18,20,25H,5-12H2,1-3H3/t15-,16+,17-,18-,20-,21-,22-,23+/m0/s1

28444-97-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 16,17-Epoxy-21-acetoxypregnenolone

1.2 Other means of identification

Product number -
Other names 16,17-EPOXY-21-ACETOXYPREGNENOLONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28444-97-5 SDS

28444-97-5Relevant articles and documents

Synthesis and cytotoxic effect of pregnenolone derivatives with one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3

Chávez-Riveros, Alejandra,Cruz Noriega, Abigail,Ramírez Apan, María Teresa,Miranda, Luis D.,Bratoeff, Eugene

, p. 37 - 45 (2018)

Four series of pregnenolone derivatives having one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3 were synthetized to compare their cytotoxicity effect. The final compounds were evaluated on three human cancer cell lines: PC-3 (prostate cancer), MCF-7 (breast cancer), SKLU-1 (lung cancer) and a noncancerous cell line HGF (human gingival fibroblast). Two steroids with a 4-fluorinated benzoic acid ester at C-21 were the most active against lung cancer cell line with IC50 of 13.1 ± 1.2 and 12.8 ± 0.5 μM and showed a low percentage of cytotoxicity for noncancerous cells (27.63 ± 2.3 and 18.39 ± 1.2% in the screening at 50 μM).

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