284474-77-7

Basic information

• Product Name: 1,3-PROPANE-D6-DIOL
• Synonyms: 1,3-PROPANE-D6-DIOL;1,1,2,2,3,3-hexadeuteriopropane-1,3-diol
• CAS NO: 284474-77-7
• Molecular Formula: C₃H₈O₂
• Molecular Weight: 82.13
• Mol File: 284474-77-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: -27 °C(lit.)
• Boiling Point: 214 °C(lit.)
• Appearance: /
• Density: 1.107 g/mL at 25 °C
• CAS DataBase Reference: 1,3-PROPANE-D6-DIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-PROPANE-D6-DIOL(284474-77-7)
• EPA Substance Registry System: 1,3-PROPANE-D6-DIOL(284474-77-7)

Safety Data

• Hazard Codes: Xi
• Statements: 38
• Safety Statements: 36
• Hazardous Substances Data: 284474-77-7(Hazardous Substances Data)

Usage

Uses

Isotope labelled 1,3-Propanediol, a common organic reagent used in the synthesis of polymers and used in industrial organic chemistry for the synthesis of lubricants, foods, medicines and cosmetics.

Upstream product

• 4303-49-5 diethyl [²H₂]malonate 
• 83670-42-2 d₂-malonic acid 
• 36647-07-1 2,2-dideuterio-malonic acid dimethyl ester 

Downstream Products

• 284474-43-7 3-bromopropanol-d₆ 
• 144501-34-8 [1,1,2,2,3,3‐D₆]‐propane‐1,3‐diyl bis(4‐methylbenzenesulfonate) 
• 120404-22-0 [²H₆]-1,3-dibromopropane 

Relevant articles and documents

Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor

A novel series of 30 symmetric bispyridinium and related N-heteroaromatic bisquaternary salts with a propane-1,3-diyl linker was synthesized and characterized for their binding affinity at the MB327 binding site of nicotinic acetylcholine receptor (nAChR) from Torpedo californica. Compounds targeting this binding site are of particular interest for research into new antidotes against organophosphate poisoning, as therapeutically active 4-tert-butyl-substituted bispyridinium salt MB327 was previously identified as a nAChR re-sensitizer. Efficient access to the target compounds was provided by newly developed methods enabling N-alkylation of sterically hindered or electronically deactivated heterocycles exhibiting a wide variety of functional groups. Determination of binding affinities toward the MB327 binding site at the nAChR, using a recently developed mass spectrometry (MS)-based Binding Assay, revealed that several compounds reached affinities similar to that of MB327 (pKi=4.73±0.03). Notably, the newly prepared lipophilic 4-tert-butyl-3-phenyl-substituted bispyridinium salt PTM0022 (3 h) was found to have significantly higher binding affinity, with a pKi value of 5.16±0.07, thus representing considerable progress toward the development of more potent nAChR re-sensitizers.

BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AGONISTS

This invention relates to compounds (Formula (1)) that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and

Structure-property correlations in model compounds of oligomer liquid crystals

Structure-property correlations of the following model compounds for oligomer liquid crystals (LCs) have been investigated: monomers, C 6H5O(CH2)xCH3 (x = 4 and 5); dimers, C6H5O