28456-53-3

Usage

Uses

Used in Pharmaceutical Industry:
4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxois used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique structure allows it to be a promising candidate for the development of new drugs with potential applications in treating various diseases.
Used in Agricultural Industry:
4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxois used as an active ingredient in the development of agrochemicals, such as pesticides and herbicides. Its potential biological activities make it a valuable compound for enhancing crop protection and improving agricultural productivity.
It is important to handle and use 4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxowith caution, following proper safety protocols and guidelines to prevent any potential hazards or risks associated with its handling and use. Further research and studies are needed to fully understand the properties and potential applications of 4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxo-.

InChI:InChI=1/C7H10N2OS/c1-4(2)5-3-6(10)9-7(11)8-5/h3-4H,1-2H3,(H2,8,9,10,11)

Upstream product

• 17356-08-0 thiourea 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 563-80-4 3-methyl-butan-2-one 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 

Downstream Products

• 58289-27-3 6-isopropyl uracil 
• 58289-28-4 6-isopropyl-2,4-dihydroxy-5-nitropyrimidine 
• 58289-29-5 2,4-dichloro-5-nitro-6-isopropylpyrimidine 
• 58289-27-3 2,4-dihydroxy-6-isopropylpyrimidine 

Relevant academic research and scientific papers

Laccase-catalyzed green synthesis and cytotoxic activity of novel pyrimidobenzothiazoles and catechol thioethers

The laccase-catalyzed reaction between unsubstituted catechol and 2-thioxopyrimidin-4(1H)-ones using aerial O2 as the oxidant delivers novel pyrimidobenzothiazoles with high yields in an aqueous solvent system under mild reaction conditions. With 4-substituted catechols, catechol thioethers are formed exclusively. The synthetic protocols developed provide a sustainable approach for these compound classes. In addition, the cytotoxicity of the products against HepG2 cell line is reported. Most compounds exhibit antiproliferative activities with IC50 values at the micromolar level. A structure-activity relationship study will facilitate the further development of these compounds as cytotoxic agents.

JANUS KINASE INHIBITOR COMPOUNDS AND METHODS

The invention provides compounds of Formula I, stereoisomers or pharmaceutically acceptable salts thereof, wherein A, B, D, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and methods of use thereof

Structure-Activity Relations. Part 12. Antibacterial Activity of a Series of 2,4-Diamino-6-substituted 5-(4-pyridylmethylamino)pyrimidines and 2,4-Diamino-5-(4-substituted benzylamino)pyrimidines.

A series of 6-substituted 2,4-diamino-5-(4-pyridylamino)pyrimidines and of 2,4-diamino-5-(4-substituted benzylamino)pyrimidines has been prepared.Their antibacterial activity towards L. casei, S. aureus and E. coli has been investigated.These activities have been successfully correlated by Hansch-type relations.Dependence on both lipophilicity and electronic (polar) factors has been found.The results are related to the structure and interactions with the receptor.