2846-77-7

Usage

Uses

Used in Pharmaceutical Industry:
2-[(2-amino-6-chloro-4-pyrimidinyl)amino]ethanol (SALTDATA: FREE) is used as a chemical intermediate for the synthesis of various medications, leveraging its unique structure and properties to contribute to the development of new drugs and therapeutic agents.
Used in Drug Development:
In the field of drug development, 2-[(2-amino-6-chloro-4-pyrimidinyl)amino]ethanol (SALTDATA: FREE) serves as a crucial building block for creating novel compounds with potential therapeutic applications. Its versatile chemical structure allows for the design and synthesis of innovative pharmaceuticals targeting specific medical conditions.
Used in Medicinal Chemistry Research:

InChI:InChI=1/C6H9ClN4O/c7-4-3-5(9-1-2-12)11-6(8)10-4/h3,12H,1-2H2,(H3,8,9,10,11)

Upstream product

• 56-05-3 2-Amino-4,6-dichloropyrimidine 
• 141-43-5 ethanolamine 

Relevant academic research and scientific papers

Probing the: Hras -1Y i-motif with small molecules

Non-B DNA structures represent intriguing and challenging targets for small molecules. For example, the promoter of the HRAS oncogene contains multiple G-quadruplex and i-motif structures, atypical globular folds that serve as molecular switches for gene

Triamino pyrimidines and pyridines as histamine H4 receptor modulators

Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure-activity relationships evaluated for activity at the H4 receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds.

Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof

Novel pyrimidine N-oxide compounds and salts thereof, well suited for stimulating the growth of keratin fibers (e.g., the hair or the eyelashes) and/or limiting the loss thereof and/or increasing their density, have the formula (A): in which n is an integer ranging from 2 to 12; R1 is a linear or branched, saturated or unsaturated alkyl radical, optionally substituted with a group —OR′, —NR′R″ or —COOR′, R1 having from 1 to 20 carbon atoms, or is NR′R″; R2 is hydrogen, —NR3R4, —OR3, or —SR3, wherein R3 and R4, which may be identical or different, are each a linear or branched, saturated or unsaturated alkyl radical, optionally substituted with a group —OR′, —NR′R″ or —COOR′, R2 having from 1 to 20 carbon atoms, with the proviso that R3 and R4 may form part of a saturated or unsaturated ring member of 4 to 7 atoms, optionally containing at least one hetero atom; and R′ and R″, which may be identical or different, are each hydrogen or a saturated, linear or branched C1-C3 alkyl radical.

Pyrimidine compound and anti-rotavirus composition

A pyrimidine compound of the formula [I]wherein R1 is H, C1-C4 lower alkyl, halogen atom, -OH, C1-C4 lower alkoxy, C1-C6 hydroxy(lower)alkoxy or -NH2; R2 is H, -NH2 or -NHCOCH3; R3 is -NR5(CH2)i-CH2OH; R4 is H, halogen atom, -NH2, -CN, -CHO, -CH2OH, -COOH

Specific inhibitors in vitamin biosynthesis. Part 10. Synthesis of 7- and 8-substituted 7-deazaguanines

Versatile syntheses of 7- and 8-substituted 7-deazaguanines including N-alkyl derivatives have been developed by identifying selective annulation reactions with 2,6-diaminopyrimidin-4(3H)-one as substrate and β-halocarbonyl compounds as electrophiles. A new synthesis of 8-substituted 7-deazaguanines using nitrosoalkenes as electrophiles is described. With some combinations of reactants, furo[2,3-d]pyrimidines are significant products in place of or in addition to the required 7-deazaguanines [pyrrolo[2,3-d]-pyrimidin-4(3H)-ones]. When 2,4-diamino-6-chloropyrimidine was used as a substrate, imidazo-pyrimidines were produced.