28466-95-7

Basic information

• Product Name: 6-Hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester
• Synonyms: 6-Hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester
• CAS NO: 28466-95-7
• Molecular Formula: C₁₂H₁₀O₅
• Molecular Weight: 234.2
• Mol File: 28466-95-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester(28466-95-7)
• EPA Substance Registry System: 6-Hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl ester(28466-95-7)

Safety Data

• Hazardous Substances Data: 28466-95-7(Hazardous Substances Data)

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 490-78-8 2,5-Dihydroxyacetophenone 

Downstream Products

• 1027898-47-0 6-{3-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-propoxy}-4-oxo-4H-chromene-2-carboxylic acid ethyl ester 

Relevant articles and documents

LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.

CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT

Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula (I), o

Chromenon derivatives

The use of 2-(heterocyclyl-carbonyl)-chromen-4-one derivatives (I) as kinase signal transduction inhibiting, regulating and/or modulating medicaments is new. Some of the compounds (I) are new. The use of chromenone derivatives of formula (I) or their derivatives, solvates, salts or stereoisomers (including mixtures in all proportions) is claimed in the production of kinase signal transduction inhibiting, regulating and/or modulating medicaments. [Image] R 1>-R 3>H, OH, OA, phenoxy, Ar, OCOA, SO 3H, SO 3A, OSO 3H, OSO 3A, SO 2A, halo, COOH, COOA, CONH 2, NHSO 2A, COA, CHO or SO 2NH 2; or R 1>+R 2>OCH 2O or OCH 2CH 2O; Het : mono- or bicyclic, saturated, unsaturated or aromatic heterocycle containing 1-4 N, O or S heteroatoms, optionally substituted by 1-3 of =O, =S, =NH, halo, A, -(CH 2) o-Ar, -(CH 2) o-cycloalkyl, -(CH 2) o-OH, -(CH 2) o-NH 2, NO 2, CN, -(CH 2) o-COOH, -(CH 2) o-COOA, -(CH 2) o-CONH 2, -(CH 2) o-NHCOA, NHCONH 2, -(CH 2) o-NHSO 2A, CHO, COA', SO 2NH 2and/or S(O) oA; Ar : phenyl, naphthyl or biphenylyl (all optionally substituted by 1-3 of halo, A, OH, OA, NH 2, NO 2, CN, COOH, COOA, CON 2, NHCOA, NHCONH 2, NHSO 2A, CHO, COA, SO 2NH 2or S(O) oA); A : 1-10C alkyl (optionally substituted by 1-7 F); A' : 1-6C alkyl or benzyl; o : 0-2. Independent claims are included for: (a) (I) (including salts etc.) as new compounds, provided that R 1>is other than H or halo; and (b) the preparation of the new compounds (I). ACTIVITY : Cytostatic; ophthalmological; antidiabetic; antiinflammatory; antirheumatic; antiarthritic; antipsoriatic; dermatological; antiallergic; osteopathic; gynecological; vulnerary; immunosuppressive; immunostimulant; anti-HIV; nootropic; neuroprotective; antiarteriosclerotic; cardiant; vasotropic; cerebroprotective. MECHANISM OF ACTION : Tyrosine kinase inhibitor; Raf kinase inhibitor; antioxidant. 6-Hydroxy-2-(3,5-dichloropyrazine-2-carbonyl)-chromen-4-one (Ia) had IC 509.64 MicroM for inhibition of protein kinase B (PKB).