284663-84-9Relevant academic research and scientific papers
Synthesis of 2,3,4,6-tetrasubstituted quinolines from 5-substituted 2-chloroacetylaminobenzophenones
Ivanov,Grishchuk,Ivanova,Mazepa
, p. 1841 - 1844 (2007/10/03)
Cyclization of 5-substituted 2-chloroacetylaminobenzophenones by the action of NaCN or NaNO2 in dimethylformamide or dimethyl sulfoxide yields 6-substituted 4-aryl-2-hydroxy-3-cyano(nitro)quinolines. Heating of 3-cyanoquinoline derivatives in 75% H2SO4 gives 2-hydroxyquinoline-3-carboxylic acids which can be converted into the corresponding acyl chlorides and then to esters, hydrazides, and amides.
