28467-39-2

Upstream product

• 7214-50-8 5-methylcyclohex-2-en-1-one 
• 28557-00-8 phenylzinc chloride 
• 98-80-6 phenylboronic acid 
• 1026571-95-8 Methanesulfonic acid 1-methyl-3-phenyl-5-phenylsulfanylmethyl-hex-5-enyl ester 
• 1027295-76-6 4-Phenyl-6-phenylsulfanylmethyl-hept-6-en-2-ol 
• 172978-85-7 4-Phenyl-6-phenylsulfanylmethyl-hept-6-en-2-one 
• 1896-62-4 (E)-benzalacetone 
• 29490-59-3 5-methyl-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one 

Relevant academic research and scientific papers

Kinetic resolution of chiral cyclohex-2-enones by rhodium(I)/binap- catalyzed 1,2- and 1,4-additions

The feasibility of kinetic resolutions of racemic monosubstituted cyclohex-2-enones by Rh/binap-catalyzed reactions was investigated. 1,2-Addition of AlMe3 to the 5-substituted derivatives furnished allylic alcohols in the matched case, while t

Annulation Based on 6-Endo-Trig Radical Cyclization: Regioselectivity and Diastereoselectivity

The development of a annulation strategy based on sequential "two-electron" and "one-electron" allylation of β-substituted aldehydes and derivatives with the bifunctional isobutene conjunctive reagent 1 is described.The key step involves an unusual 6-endo-trig radical cyclization.Yields of 6-endo products are improved if the PhS group is oxidized to a PhSO2 group prior to cyclization.The structural factors affecting the regioselectivity and stereoselectivity of the cyclization are examined.In general, the stereoselectivity of 6-endo-trig cyclization of 5-hexenyl radicals can be rationalized by conformational analysis of chairlike transition states and can be calculated effectively with an MM2 force field model.High 6-endo regioselectivity requires a strong driving force.Fragmentable allylic groups (R3Sn, PhSO2, and to a lesser extent PhS) are shown to be sufficiently activating to achieve 6-endo regioselectivity.