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284681-49-8

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284681-49-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 284681-49-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,4,6,8 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 284681-49:
(8*2)+(7*8)+(6*4)+(5*6)+(4*8)+(3*1)+(2*4)+(1*9)=178
178 % 10 = 8
So 284681-49-8 is a valid CAS Registry Number.

284681-49-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-butan-2-yloxy-2-(3-chlorophenyl)sulfanylpyrimidin-4-amine

1.2 Other means of identification

Product number -
Other names 2-[(3-chlorophenyl)sulfanyl]-6-(1-methylpropoxy)pyrimidin-4-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:284681-49-8 SDS

284681-49-8Upstream product

284681-49-8Downstream Products

284681-49-8Relevant articles and documents

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives

Saccoliti, Francesco,Angiulli, Gabriella,Pupo, Giovanni,Pescatori, Luca,Madia, Valentina Noemi,Messore, Antonella,Colotti, Gianni,Fiorillo, Annarita,Scipione, Luigi,Gramiccia, Marina,Di Muccio, Trentina,Di Santo, Roberto,Costi, Roberta,Ilari, Andrea

, p. 304 - 310 (2017/11/10)

The study presented here aimed at identifying a new class of compounds acting against Leishmania parasites, the causative agent of Leishmaniasis. For this purpose, the thioether derivatives of our in-house library have been evaluated in whole-cell screening assays in order to determine their in vitro activity against Leishmania protozoan. Among them, promising results have been achieved with compound RDS 777 (6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine) (IC50=29.43 μM), which is able to impair the mechanism of the parasite defence against the reactive oxygen species by inhibiting the trypanothione reductase (TR) with high efficiency (Ki 0.25 ± 0.18 μM). The X-ray structure of L. infantum TR in complex with RDS 777 disclosed the mechanism of action of this compound that binds to the catalytic site and engages in hydrogen bonds the residues more involved in the catalysis, namely Glu466', Cys57 and Cys52, thereby inhibiting the trypanothione binding and avoiding its reduction.

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