28478-40-2 Usage
Chemical structure
A phenyl ring with a chlorine atom at the 5th position, a methoxy group at the 2nd position, and a methyl group at the 4th position, attached to an ethanone (ketones) group.
Type of compound
Aromatic ketone derivative
Functional groups
Chlorine atom, methoxy group, methyl group, and a ketone group
Usage
Intermediate in the synthesis of pharmaceuticals and other organic compounds
Industries
Pharmaceuticals, agrochemicals, flavors and fragrances
Physical state
Likely a solid at room temperature (based on molecular size and complexity)
Solubility
Likely soluble in organic solvents such as ethanol, methanol, and acetone (due to the presence of the ketone group)
Stability
Stable under normal conditions, but may be sensitive to heat, light, or strong bases (due to the presence of the methoxy group)
Reactivity
May react with strong nucleophiles, electrophiles, or bases (due to the presence of the ketone and methoxy groups)
Hazards
Potential irritant or toxic (due to the presence of the chlorine atom and aromatic ring)
Storage
Should be stored in a cool, dry place, away from heat, light, and strong bases (to maintain stability)
Disposal
Should be disposed of according to local regulations for hazardous chemicals (due to potential toxicity or reactivity)
Check Digit Verification of cas no
The CAS Registry Mumber 28478-40-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,4,7 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 28478-40:
(7*2)+(6*8)+(5*4)+(4*7)+(3*8)+(2*4)+(1*0)=142
142 % 10 = 2
So 28478-40-2 is a valid CAS Registry Number.
28478-40-2Relevant academic research and scientific papers
Iridium-Catalyzed C(sp3)?H Addition of Methyl Ethers across Intramolecular Carbon–Carbon Double Bonds Giving 2,3-Dihydrobenzofurans
Ohmura, Toshimichi,Kusaka, Satoshi,Torigoe, Takeru,Suginome, Michinori
supporting information, p. 4448 - 4453 (2019/09/16)
Intramolecular addition of an O-methyl C(sp3)?H bond across a carbon-carbon double bond occurs in the iridium-catalyzed reaction of methyl 2-(propen-2-yl)phenyl ethers. The Ir/(S)-DTBM-SEGPHOS catalyst promotes the reaction efficiently in toluene at 110–135 °C to afford 3,3-dimethyl-2,3-dihydrobenzofurans. Enantioselective C(sp3)?H addition is achieved in the reaction of methyl 2-(1-siloxyethenyl)phenyl ethers, affording enantioenriched 3-hydroxy-2,3-dihydrobenzofuran derivatives with up to 96% ee. (Figure presented.).
Methods of protection against emesis in mammals by administration of a heterocyclic benzamide
-
, (2008/06/13)
The heterocyclic benzamides of this invention are particularly effective for the treatment of emesis in mammals. For example, when they are administered to dogs in relatively small dosage, they afford 100% protection against vomiting. They are also non-toxic in dosages for effecting complete control of vomiting.
