285-59-6

Usage

Uses

Used in Organic Synthesis:
3-Azabicyclo[3.1.0]hexane is used as a building block in organic synthesis for the creation of various compounds. Its unique structure allows for the formation of diverse chemical entities, contributing to the development of new molecules with potential applications in various fields.
Used in Pharmaceutical Industry:
3-Azabicyclo[3.1.0]hexane is used as a precursor in the production of pharmaceuticals. Its ability to be modified and incorporated into complex molecular structures makes it a valuable component in the synthesis of new drugs and therapeutic agents.
Used in Agrochemical Production:
In the agrochemical industry, 3-Azabicyclo[3.1.0]hexane serves as a precursor for the synthesis of various agrochemicals. Its versatility in chemical reactions enables the development of new compounds with potential applications in agriculture, such as pesticides and herbicides.
Used in Material Development:
3-Azabicyclo[3.1.0]hexane has potential applications in the development of new materials. Its unique chemical properties and structure make it a promising candidate for the creation of innovative materials with specific properties tailored for various industries.
Used in Drug Delivery Systems:
3-Azabicyclo[3.1.0]hexane has been studied for its potential use as a drug delivery system. Its ability to interact with other molecules and encapsulate active pharmaceutical ingredients makes it a promising candidate for improving the efficacy and targeted delivery of drugs.
Used in Asymmetric Synthesis:
3-Azabicyclo[3.1.0]hexane has shown promise in the field of asymmetric synthesis due to its unique chemical structure. It can be used as a chiral building block or a catalyst in the synthesis of enantiomerically pure compounds, which are important in the pharmaceutical industry for the development of single-enantiomer drugs.

Upstream product

• 73799-64-1 3-azabicyclo[3.1.0]hexane hydrochloride 
• 73799-64-1 3-Azabicyclo<3.1.0>hexane hydrochloride 
• 73799-63-0 3-benzyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione 
• 710-43-0 cis-cyclopropane-1,2-dicarboxylic acid diethyl ester 
• 696-74-2 cis-1,2-cyclopropanedicarboxylic acid 
• 5617-74-3 3-oxabicyclo[3.1.0]hexane-2,4-dione 
• 70110-45-1 3-benzyl-3-aza-bicyclo[3.1.0]hexane 
• 5617-69-6 3-aza-bicyclo[3.1.0]hexane-2,4-dione 

Downstream Products

• 115182-91-7 3-azabicyclo-(3.1.0)hexane-2-carbonitrile 
• 681425-48-9 [4-(3-azabicyclo[3.1.0]hex-3-yl)-3,5-difluorophenyl]carbamic acid benzyl ester 
• 681425-51-4 [4-(3-azabicyclo[3.1.0]hex-3-yl)-3-fluorophenyl]carbamic acid benzyl ester 
• 681425-50-3 4-(3-aza-bicyclo[3.1.0]hex-3-yl)-3,5-difluoro-phenylamine 
• 681425-53-6 4-(3-aza-bicyclo[3.1.0]hex-3-yl)-3-fluoro-phenylamine 
• 681425-49-0 3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane 
• 681425-52-5 3-(2-fluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hexane 

Relevant academic research and scientific papers

High Resolution 1H NMR Studies of Cyclic N-Nitrosoamines

Molecular modeling by molecular mechanics (MM2) calculations were used to predict conformational preferences of cyclic N-nitrosoamines.The results were compared with 1H NMR data.The observed geminal coupling constants 2J were considerably stronger for syn than for anti α-methylene protons and thus appear to be very useful for configurational predictions.The long-range 4J couplings across the nitrogen atom were observed directly from the 1D spectra. - Keywords: NMR 1H NMR Molecular modeling Cyclic N-Nitrosamines 1H,1H Spin-Spin coupling

NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF

The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.

NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF

The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.

NOVEL AMINOALCOHOL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

The invention relates to aminoalcohol-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one aminoalcohol-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the aminoalcohol- substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

The synthesis and structure-activity relationships of novel dipeptidyl peptidase IV inhibitors replacing the classical cyanopyrrolidine P1 group with other small nitrogen heterocycles are described. A unique potency enhancement was achieved with β-branched natural and unnatural amino acids, particularly adamantylglycines, linked to a (2S,3R)-2,3-methanopyrrolidine based scaffold.

Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine

Novel derivatives of Tolterodine (1) and Oxybutynin (2) have been designed using conformationally restricted azabicyclics as replacement for open-chain amines. The synthesis and structure-activity relationships are presented.

Aza bicyclo[3,1,0]hexane intermediates useful in the synthesis of quinolones

This invention relates to certain azabicyclo hexane intermediates and processes for making and using the azabicyclo hexane intermediates. The intermediates are useful in the synthesis of quinolone antibacterial agents.