285138-30-9

Basic information

• Product Name: (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]thymine
• Synonyms: (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]thymine
• CAS NO: 285138-30-9
• Molecular Weight: 344.367
• Mol File: 285138-30-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]thymine(CAS DataBase Reference)
• NIST Chemistry Reference: (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]thymine(285138-30-9)
• EPA Substance Registry System: (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]thymine(285138-30-9)

Safety Data

• Hazardous Substances Data: 285138-30-9(Hazardous Substances Data)

Upstream product

• 283598-18-5 (1R,2R,3S)-1-amino-2,3-bis(benzoyloxymethyl)cyclobutane 
• 283598-17-4 (1R,2R,3S)-1-azido-2,3-bis(benzoyloxymethyl)cyclobutane 
• 65-71-4 thymin 
• 132294-18-9 <1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester 
• 207345-00-4 (1'R,2'R,3'S)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]thymine 

Downstream Products

• 283598-22-1 (1'R,2'R,3'S)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-thymine 

Relevant articles and documents

Synthesis and hybridization property of oligonucleotides containing carbocyclic oxetanocins

Oligonucleotides containing enantiomeric carbocyclic oxetanocins possessing adenine, thymine, guanine and cytosine were synthesized from an optically active cyclobutane derivative. Their hybridization properties with the complementary oligonucleotides were studied using melting point method, CD spectroscopy, and mixing curve method (Job plots). The artificial nucleotides possessing adenine, guanine and cytosine bases show tendency to form complexes more strongly with ribonucleotide than deoxyribonucleotide. These complexes are triplexes consisting of purine and pyrimidine in 1:2 ratio. Such triplex formation is observed both under high (1 M NaCl) and low salt conditions (0.1 M NaCl). (C) 2000 Elsevier Science Ltd.

High pressure in enzyme catalyzed organic reactions

Adenosine deaminase and lipases catalyzed hydrolysis under high pressure were described. The hydrolysis by both enzymes was facilitated by high pressures. This technique was used for the kinetical resolution of racemic highly modified nucleosides having biological activities.