285139-20-0

Basic information

• Product Name: (1R,3S,4R)-3-((1S,3S)-3-Hydroxy-3-phenyl-1-p-tolyl-propylsulfanylmethyl)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one
• Synonyms: (1R,3S,4R)-3-((1S,3S)-3-Hydroxy-3-phenyl-1-p-tolyl-propylsulfanylmethyl)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one
• CAS NO: 285139-20-0
• Molecular Weight: 422.632
• Mol File: 285139-20-0.mol

Chemical Properties

• CAS DataBase Reference: (1R,3S,4R)-3-((1S,3S)-3-Hydroxy-3-phenyl-1-p-tolyl-propylsulfanylmethyl)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3S,4R)-3-((1S,3S)-3-Hydroxy-3-phenyl-1-p-tolyl-propylsulfanylmethyl)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one(285139-20-0)
• EPA Substance Registry System: (1R,3S,4R)-3-((1S,3S)-3-Hydroxy-3-phenyl-1-p-tolyl-propylsulfanylmethyl)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one(285139-20-0)

Safety Data

• Hazardous Substances Data: 285139-20-0(Hazardous Substances Data)

Upstream product

• 16161-84-5 <1R-(1β,4β)>-3-methylene-1,7,7-trimethylbicyclo<2.2.1>heptan-2-one 
• 464-49-3 (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 
• 22252-14-8 (E)-3-(4-methylphenyl)-1-phenyl-2-propen-1-one 
• 285139-14-2 (1R,2R,3S,4R)-3-Mercaptomethyl-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol 

Relevant articles and documents

Highly enantioselective synthesis of 1,3-mercaptoalcohols from α,β- unsaturated ketones: Asymmetric bifunctional group exchange reaction

Optically active 1,3-mercapto alcohols were synthesized from α,β- unsaturated ketones using a chiral reagent B and dimethylaluminum chloride in two steps. The transformation involved a tandem Michael addition-MPV reduction and a base-catalyzed elimination. The two newly created chiral carbons in trans-chalcone derivatives were enantioselectively controlled to a high degree. Using the above transformation, an asymmetric bifunctional group exchange reaction between the substrate and chiral reagent was developed. (C) 2000 Elsevier Science Ltd.