28539-33-5

Upstream product

• 76357-48-7 9-benzyl-1,6-dihydro-8-azapurin-2-one 
• 50533-88-5 (5-amino-1-benzyl-1H-[1,2,3]triazol-4-ylmethyl)-carbamic acid ethyl ester 

Downstream Products

• 73286-55-2 C₁₁H₁₂N₅S₂^(1-) 
• 76055-32-8 ammonium N-(4-amino-3-benzyl-3H-1,2,3-triazol-5-ylmethyl)dithiocarbamate 
• 73286-56-3 3-benzyl-3,7-dihydro-1,2,3-triazolo<4,5-d><1,3>thiazine-5(4H)-thione 
• 73286-58-5 bis-(4-amino-3-benzyl-3H-1,2,3-triazol-5-ylmethyl) sulphide 
• 73286-57-4 Dithiocarbamic acid 5-amino-1-benzyl-1H-[1,2,3]triazol-4-ylmethyl ester 
• 77976-42-2 4-amino-3-benzyl-5-oxamoylaminomethyl-3H-1,2,3-triazole 
• 73286-27-8 3-benzyl-5-hydrazino-3,7-dihydro-1,2,3-triazolo<4,5-d><1,3>thiazine 
• 73286-25-6 3-benzyl-5-methylthio-3,7-dihydro-1,2,3-triazolo<4,5-d><1,3>thiazine 
• 73286-26-7 5-amino-3-benzyl-3,7-dihydro-1,2,3-triazolo<4,5-d><1,3>thiazine 
• 76055-36-2 O-ethyl N-(4-amino-3-benzyl-3H-1,2,3-triazol-5-ylmethyl) monothiocarbamate 
• 76055-35-1 S-methyl N-(4-amino-3-benzyl-3H-1,2,3-triazol-5-ylmethyl)dithiocarbamate 
• 77976-48-8 N,N'-bis(4-amino-3-benzyl-3H-1,2,3-triazole-5-ylmethyl)oxamide 
• 50486-80-1 4-amino-3-benzyl-5-ethoxalylaminomethyl-3H-1,2,3-triazole 
• 76357-53-4 tosylate of 2-amino-9-benzyl-1,6-dihydro-8-azapurine 

Relevant academic research and scientific papers

2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE DERIVATIVES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS FOR TREATING VASCULITIS AND INFLAMMATORY DISEASES

The present invention relates to derivatives of formula (I) wherein Ring A, X, Y, Z, RA, R1, R2, R3 and R4 are The present invention discloses derivatives of formula (I), wherein Ring A, X, Y, Z, RA, R1, R2, R3 and R4 are as described in the description, and in particular e.g. 2,4,6,7-tetrahydro-pyrazolo[4,3- d]pyrimidin-5-one derivatives and related compounds, their preparation, pharmaceutically acceptable salts thereof, their use as pharmaceuticals, pharmaceutical compositions containing one or more compounds of formula (I), and especially their use as C5a receptor modulators for treating e.g. vasculitis and inflammatory diseases.

v-Triazolo[4,5-d]pyrimidines (8-azapurines). Part 22. Synthesis of 2-amino- and 2-oxo-derivatives of N-alkyl-1,6-dihydro-8-azapurines from the corresponding 4-amino-5-aminomethyl-1,2,3-triazoles

2-Amino-1,6-dihydro-8-azapurines (1c-e), alkylated on a ring-nitrogen atom, were synthesized from corresponding N-alkyl-4-amino-5-aminomethyl-1,2,3- triazoles, e.g. (2a), and cyanogen bromide. 1,6-dihydro-8-azapurin-2-ones (3), similarly alkylated, were o