285552-89-8Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationships of phthalimide- phenylpiperazines: A novel series of potent and selective {1a)-adrenergic receptor antagonists
Kuo, Gee-Hong,Prouty, Catherine,Murray, William V.,Pulito, Virginia,Jolliffe, Linda,Cheung, Peter,Varga, Sally,Evangelisto, Mary,Wang, Jian
, p. 2183 - 2195 (2000)
Beginning from the screening hit and literature α1-adrenergic compounds, a hybridized basic skeleton A was proposed as the pharmacophore for potent and selective α(1a)-AR antagonists. Introduction of a hydroxy group to increase the flexibility
Design, synthesis and biological evaluation of pyridine-phenylpiperazines: A novel series of potent and selective α(1a)-adrenergic receptor antagonist
Kuo, Gee-Hong,Prouty, Catherine,Murray, William V.,Pulito, Virginia,Jolliffe, Linda,Cheung, Peter,Varga, Sally,Evangelisto, Mary,Shaw, Charles
, p. 2263 - 2275 (2007/10/03)
Beginning from the screening hit and literature α1-adrenergic compounds, a hybridized basic skeleton A was proposed as the pharmacophore for potent and selective α(1a)-AR antagonists. Introduction of a hydroxy group to increase the flexibility
