285559-81-1

Basic information

• Product Name: (4-amino-2-chloro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone
• Synonyms: (4-amino-2-chloro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone
• CAS NO: 285559-81-1
• Molecular Weight: 357.84
• Mol File: 285559-81-1.mol

Chemical Properties

• CAS DataBase Reference: (4-amino-2-chloro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-amino-2-chloro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone(285559-81-1)
• EPA Substance Registry System: (4-amino-2-chloro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone(285559-81-1)

Safety Data

• Hazardous Substances Data: 285559-81-1(Hazardous Substances Data)

Upstream product

• 285559-79-7 (S)-(+)-3,4,5,10,11,11a-hexahydro-1H-2-oxa-4a,10-diazadibenzo[a,d]cycloheptene 
• 285559-80-0 (2-chloro-4-nitro-phenyl)-(3,4,11,11a-tetrahydro-1H,5H-2-oxa-4a,10-diaza-dibenzo[a,d]cyclohepten-10-yl)-methanone 
• 7073-36-1 2-chloro-4-nitrobenzoyl chloride 

Relevant articles and documents

Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates

Vasopressin receptor antagonists can elicit ion-sparing diuretic effects (i.e., aquaresis) in vivo by blunting the action of the circulating hypophyseal hormone arginine vasopressin. We have identified two new series of basic tricyclic benzodiazepines, represented by general structure 1, which contain compounds that bind with high affinity to human V2 receptors. For example, (S)-(+)-8 and 5 are potent and selective V2 receptor antagonists with pronounced aquaretic activity in rats on oral administration.