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28556-81-2 Usage


2,6-Dimethylphenyl isocyanate is a light yellow liquid with unique chemical properties that make it suitable for various applications in different industries. It is an organic compound characterized by its isocyanate functional group, which is highly reactive and forms the basis for its diverse uses.


Used in Chemical Synthesis:
2,6-Dimethylphenyl isocyanate is used as a key intermediate in the synthesis of various organic compounds. Its reactivity allows it to be employed in the preparation of derivatized β-cyclodextrins, which are used as chiral stationary phases in normal-phase liquid chromatography. This application is crucial for the separation and analysis of enantiomers in pharmaceutical and chemical industries.
Used in Coordination Chemistry:
In the field of coordination chemistry, 2,6-Dimethylphenyl isocyanate is used to synthesize tris(2,6-dimethylphenylimido)methylrhenium(VII) complexes. These complexes exhibit unique electronic and structural properties, making them valuable for studying metal-ligand interactions and potential applications in homogeneous catalysis.
Used in Pharmaceutical Industry:
2,6-Dimethylphenyl isocyanate is also utilized in the synthesis of 1-(2-isopropylphenyl)-3-(2,6-dimethylphenyl)urea, a compound with potential pharmaceutical applications. 2,6-Dimethylphenyl isocyanate's structure and properties make it a candidate for further development and testing in the search for new therapeutic agents.
Overall, 2,6-Dimethylphenyl isocyanate is a versatile compound with a wide range of applications across various industries, including chemical synthesis, coordination chemistry, and the pharmaceutical sector. Its unique properties and reactivity make it an essential component in the development of new materials and compounds with potential benefits for society.

Check Digit Verification of cas no

The CAS Registry Mumber 28556-81-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,5,5 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 28556-81:
142 % 10 = 2
So 28556-81-2 is a valid CAS Registry Number.

28556-81-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L12805)  2,6-Dimethylphenyl isocyanate, 98%   

  • 28556-81-2

  • 1g

  • 211.0CNY

  • Detail
  • Alfa Aesar

  • (L12805)  2,6-Dimethylphenyl isocyanate, 98%   

  • 28556-81-2

  • 5g

  • 452.0CNY

  • Detail
  • Alfa Aesar

  • (L12805)  2,6-Dimethylphenyl isocyanate, 98%   

  • 28556-81-2

  • 25g

  • 1939.0CNY

  • Detail
  • Aldrich

  • (252336)  2,6-Dimethylphenylisocyanate  99%

  • 28556-81-2

  • 252336-5G

  • 896.22CNY

  • Detail
  • Aldrich

  • (252336)  2,6-Dimethylphenylisocyanate  99%

  • 28556-81-2

  • 252336-25G

  • 3,446.82CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier

Product name 2-isocyanato-1,3-dimethylbenzene

1.2 Other means of identification

Product number -
Other names 2-Isocyanato-1,3-dimethylbenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28556-81-2 SDS

28556-81-2Relevant articles and documents


Dunkin, Ian R.,Donnelly, Thomas,Lockhart, Thomas S.

, p. 359 - 362 (1985)

Photolysis of 2,6-dimethylphenyl azide on N2 matrices at 12K gives 2,6-dimethylphenylnitrene; in presence of CO, the nitrene forms the corresponding isocyanate, while on shorter wavelength irradiation, it undergoes an inefficient rearrangement to an azacycloheptatetraene.

Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4

Li, Chuansheng,Shan, Yuanyuan,Sun, Ying,Si, Ru,Liang, Liyuan,Pan, Xiaoyan,Wang, Binghe,Zhang, Jie

, p. 506 - 518 (2017/11/14)

Herein, we embarked on a structural optimization campaign aiming at the discovery of second generation anti-angiogenesis agents with our previously reported BPS-7 as lead compound. A library of 27 compounds has been afforded based on the highly conserved ATP-binding pocket of VEGFR-2, Tie-2, and EphB4. Several title compounds exhibited simultaneous inhibitory effects against three angiogenic RTKs. These compounds with a ‘triplet’ inhibition profile have been identified as novel anti-angiogenic and anticancer agents. The representative VDAU11 displayed prominent anti-angiogenic and anticancer potency and could be considered as a candidate for further optimization. These results indicate that N-(pyridin-2-yl)acrylamide could serve as a novel hinge-binding group of triple inhibitors.

Discovery of novel VEGFR-2 inhibitors. Part 5: Exploration of diverse hinge-binding fragments via core-refining approach

Shan, Yuanyuan,Gao, Hongping,Shao, Xiaowei,Wang, Jinfeng,Pan, Xiaoyan,Zhang, Jie

, p. 80 - 90 (2015/09/15)

Pathological angiogenesis plays a critical role in numerous diseases including malignancy. VEGFR-2 is the central regulators in angiogenesis and has become a promising target for anticancer drug design. We have identified a novel biphenyl-aryl urea incorporated with salicyladoxime (BPS-7) as potent VEGFR-2 inhibitor. As a continuation to our previous research, various aromatic-heterocyclic were introduced as hinge-binding fragment via a core-refining approach. Interestingly, many compounds exhibited comparable VEGFR-2 inhibition to Sorafenib. In particular, 12e and 12o displayed excellent VEGFR-2 inhibitory activity with IC50 values of 0.50 nM and 0.79 nM, respectively. Several title compounds showed considerable antiproliferative activity against A549 and SMMC-7721 cells. In addition, molecular docking was performed to rationalize the efficiency of the better compounds. These results will be instructive for further inhibitor design and optimization.

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