28566-14-5

Usage

Uses

Used in Pharmaceutical Industry:
6,7-Dihydro-5H-1-pyridin-5-one is utilized as a key building block in the synthesis of various pharmaceuticals. Its chemical structure allows for the development of new drugs with potential therapeutic applications, making it an essential component in medicinal chemistry.
Used in Organic Compounds Synthesis:
6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE is used as a precursor in the synthesis of a range of organic compounds. Its reactivity and stability contribute to the creation of diverse organic molecules for various applications, including materials science and specialty chemicals.
Used in Agrochemical Production:
6,7-Dihydro-5H-1-pyridin-5-one is employed in the production of agrochemicals, where it serves as a fundamental component in the development of pesticides, herbicides, and other agricultural chemicals. Its role in these products is crucial for enhancing crop protection and yield.
Used in Dye Manufacturing:
In the dye industry, 6,7-Dihydro-5H-1-pyridin-5-one is used for the manufacturing of dyes. Its chemical properties allow for the creation of dyes with specific color characteristics and stability, which are important for various industrial applications, including textiles and printing inks.

InChI:InChI=1/C8H7NO/c10-8-4-3-7-6(8)2-1-5-9-7/h1-2,5H,3-4H2

Upstream product

• 533-37-9 2,3-cyclopentenopyridine 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 3859-41-4 1,3-cyclopentadione 
• 624-67-9 Propargylic aldehyde 
• 28566-12-3 3-amino-cyclopent-2-en-1-one 

Downstream Products

• 1065609-70-2 6,7-dihydro-5H-cyclopenta[b]pyridin-5-ol 

Relevant academic research and scientific papers

The improved preparation of 7,8-dihydro-quinoline-5(6H)-one and 6,7- dihydro-5H-1-pyrindin-5-one

Compounds 7,8-dihydroquinoline-5(6H)-one (3) and 6,7-dihydro-5H-1- pyrindin-5-one (5) are formed by new methods from 1,3-diketone compound, ammonium acetate and 1,1,3,3-tetraethoxylpropane.

Selective Electrochemical Oxygenation of Alkylarenes to Carbonyls

An efficient electrochemical method for benzylic C(sp3)-H bond oxidation has been developed. A variety of methylarenes, methylheteroarenes, and benzylic (hetero)methylenes could be converted into the desired aryl aldehydes and aryl ketones in moderate to excellent yields in an undivided cell, using O2 as the oxygen source and lutidinium perchlorate as an electrolyte. On the basis of cyclic voltammetry studies, 18O labeling experiments, and radical trapping experiments, a possible single-electron transfer mechanism has been proposed for the electrooxidation reaction.

Preparation method of 6,7-dihydro-5H-cyclopentadieno[b] pyridine-5-one

The invention provides a preparation method of 6,7-dihydro-5H-cyclopentadieno[b] pyridine-5-one, and the preparation method comprises the following steps: by using a compound (I) as a substrate, Fe as a catalyst, a 50% hydrogen peroxide aqueous solution as an oxide and acetonitrile as a solvent, reacting at 50 DEG C for 24 hours to obtain a crude product, and carrying out column chromatography to obtain a pure compound (II). The method for preparing the compound (II) is mild in reaction condition, easy to purify, simple to operate and high in yield.

Electrochemical benzylic oxidation of C-H bonds

Oxidized products have become increasingly valuable as building blocks for a wide variety of different processes and fine chemistry, especially in the benzylic position. We report herein a sustainable protocol for this transformation through C-H functionalization and is performed using electrochemistry as the main power source and tert-butyl hydroperoxide as the radical source for the C-H abstraction. The temperature conditions reported here do not increase above 50 °C and use an aqueous-based medium. A broad substrate scope is explored, along with bioactive molecules, to give comparable and increased product yields when compared to prior reported literature without the use of electrochemistry.

Iron-catalyzed oxidative functionalization of C(sp3)-H bonds under bromide-synergized mild conditions

An efficient oxidation and functionalization of C-H bonds with an inorganic-ligand supported iron catalyst and hydrogen peroxide to prepare the corresponding ketones was achieved using the bromide ion as a promoter. Preliminary mechanistic investigations indicated that the bromide ion can bind to FeMo6 to form a supramolecular species (FeMo6·2Br), which can effectively catalyze the reaction.

GHRELIN O-ACYLTRANSFERASE INHIBITORS

This invention relates to novel compounds according to Formula (I) which are inhibitors of ghrelin O-acyltransferase (GOAT), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment

Selective C(sp3)?H Aerobic Oxidation Enabled by Decatungstate Photocatalysis in Flow

A mild and selective C(sp3)?H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C?H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (?)-ambroxide, pregnenolone acetate, (+)-sclareolide, and artemisinin, exemplifies the utility of this new method.

Development of a Flow Photochemical Aerobic Oxidation of Benzylic C-H Bonds

A continuous mesofluidic process has been developed for benzylic C-H oxidation with moderate to good yields using a photocatalyst (riboflavin tetraacetate, RFT) activated by a UV lamp and an iron additive [Fe(ClO4)2] via incorporation of singlet oxygen (1O2) for the direct formation of oxidized C=O or CH-OH compounds.

Ketone or aldehyde synthetic method by using manganese compound to conduct catalytic oxidation of pyridine compound

The present invention discloses a ketone or aldehyde synthetic method by using a manganese compound to conduct catalytic oxidation of a pyridine compound. Pyridine compounds containing substituent groups are used as a reaction substrate, the manganese compound is used as a catalyst, one or more than two of water, tertiary butanol, acetonitrile, ethyl acetate, or dichloromethane are used as a solvent, a peroxide is used as an oxygen source, a reaction is conducted at a temperature of 25-50 DEG C for 12-48 h, so that the C-H bond of the side chain of the pyridine is oxidized to an ketone or aldehyde by one step, and a reaction crude product is processed to obtain a final product. The preparation method is mild in reaction conditions, less in catalyst use amount, high in atom economy, and simple in operation, has a wide suitable range of substrates, and has industrial applicability.

Direct oxidation of the Csp3–H bonds of N-heterocyclic compounds to give the corresponding ketones using a reusable heterogeneous MnOx-N@C catalyst

Novel reusable MnOx-N@C catalyst has been developed for the direct oxidation of N-heterocycles under solvent-free conditions using TBHP as benign oxidant to give the corresponding N-heterocyclic ketones. The catalytic system exhibited a broad substrate scope and excellent regioselectivity, as well as being amenable to gram-scale synthesis. This MnOx-N@C catalyst also showed good reusability and was successfully recycled six times without any significant loss of activity.