28566-14-5

Basic information

• Product Name: 6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE
• Synonyms: 6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE;6,7-DIHYDRO-5H-[1]PYRINDIN-5-ONE;6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-5-ONE;5H-cyclopenta[b]pyridine-5-one,6,7-dihydro-;6,7-dihydrocyclopenta[b]pyridin-5-one;5H-Cyclopenta[b]pyridin-5-one, 6,7-dihydro-;6,7-Dihydro-5-oxo-5H-cyclopenta[b]pyridine;5H,6H,7H-cyclopenta[b]pyridin-5-one
• CAS NO: 28566-14-5
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.15
• Product Categories: pharmacetical;Pyridine Derivertives;Fused Ring Systems
• Mol File: 28566-14-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 64-66 °C
• Boiling Point: 247.408 °C at 760 mmHg
• Flash Point: 109.786 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 0.0257mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.47±0.20(Predicted)
• CAS DataBase Reference: 6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE(28566-14-5)
• EPA Substance Registry System: 6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE(28566-14-5)

Safety Data

• Hazardous Substances Data: 28566-14-5(Hazardous Substances Data)

Usage

General Description

6,7-Dihydro-5H-1-pyridin-5-one, also known as 5,6-dihydropyridin-5-one or 6,7-dihydro-5H-pyridin-5-one, is a chemical compound with the formula C5H5NO. It is a heterocyclic compound that contains a pyridin-5-one ring structure. 6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE is a stable, colorless solid that is soluble in organic solvents. It is used as a building block in the synthesis of various pharmaceuticals and organic compounds, as well as in the production of agrochemicals and dyes. 6,7-Dihydro-5H-1-pyridin-5-one has a wide range of applications in the chemical and pharmaceutical industries due to its versatile reactivity and stability.

InChI:InChI=1/C8H7NO/c10-8-4-3-7-6(8)2-1-5-9-7/h1-2,5H,3-4H2

Upstream product

• 533-37-9 2,3-cyclopentenopyridine 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 3859-41-4 1,3-cyclopentadione 
• 624-67-9 Propargylic aldehyde 
• 28566-12-3 3-amino-cyclopent-2-en-1-one 

Downstream Products

• 1065609-70-2 6,7-dihydro-5H-cyclopenta[b]pyridin-5-ol 

Relevant articles and documents

The improved preparation of 7,8-dihydro-quinoline-5(6H)-one and 6,7- dihydro-5H-1-pyrindin-5-one

Compounds 7,8-dihydroquinoline-5(6H)-one (3) and 6,7-dihydro-5H-1- pyrindin-5-one (5) are formed by new methods from 1,3-diketone compound, ammonium acetate and 1,1,3,3-tetraethoxylpropane.

Preparation method of 6,7-dihydro-5H-cyclopentadieno[b] pyridine-5-one

The invention provides a preparation method of 6,7-dihydro-5H-cyclopentadieno[b] pyridine-5-one, and the preparation method comprises the following steps: by using a compound (I) as a substrate, Fe as a catalyst, a 50% hydrogen peroxide aqueous solution as an oxide and acetonitrile as a solvent, reacting at 50 DEG C for 24 hours to obtain a crude product, and carrying out column chromatography to obtain a pure compound (II). The method for preparing the compound (II) is mild in reaction condition, easy to purify, simple to operate and high in yield.

Iron-catalyzed oxidative functionalization of C(sp3)-H bonds under bromide-synergized mild conditions

An efficient oxidation and functionalization of C-H bonds with an inorganic-ligand supported iron catalyst and hydrogen peroxide to prepare the corresponding ketones was achieved using the bromide ion as a promoter. Preliminary mechanistic investigations indicated that the bromide ion can bind to FeMo6 to form a supramolecular species (FeMo6·2Br), which can effectively catalyze the reaction.