28567-37-5Relevant academic research and scientific papers
Antiviral phosphonate nucleotides
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, (2008/06/13)
The present invention relates to a novel nucleotide analogue having the general formula (I) and pharmaceutically acceptable salts, esters, or salt of such esters: wherein n, X, Q U R1′, R1, Z and R2are defined here within. The compounds object
Epothilone analogs
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, (2008/06/13)
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancer agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the anlogs are demonstrated to have a superior cytotoxic activities as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.
Process for the preparation of the (R) stereoisomer of the monobutyric ester of 2,2-bis(hydroxymethyl)-tetrahydrofuran, its use in preparing stereoisomers of pharmacologically active compounds, and certain specific stereoisomers produced thereby
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, (2008/06/13)
A process for preparing the (R) stereoisomer of 2,2-bis(hydroxmethyl)-tetrahydrofuran monobutyrate comprising subjecting the dibutyric ester of the 2,2-bis(hydroxymethyl)-tetrahydrofuran to enzymatic hydrolysis. The invention also relates to the novel (R)
Process for carbapenem intermediates
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, (2008/06/13)
A novel intermediate for synthesizing 1 β-alkyl-1-carbapenem, i.e., 4 β-(1 β-alkyl-2-carboxyprop-2-enyl)azetidin-2-one (II), is prepared stereoselectively by treating 4-(leaving group substituted)azetidin-2-one (I) with trans-2-(leaving group substituted)-methyl-3-alkylacrylic acid (III) and a reducing metal. STR1 wherein R1 is hydrogen, alkyl, or substituted alkyl; R2 is optionally substituted alkyl; R3 is hydrogen or a carboxy-protecting group; and R4 and R5 each is a leaving group.
Novel polysaccharides novel macromolecular conjugates of the polysaccharides
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, (2008/06/13)
Synthesis of oligomeric subunits of the poly(ribosyl-ribitol-phosphate) capsular polysaccharide found on Haemophilus influenzaetype b bacteria. The covalent attachment of these compounds to immunogenic proteins without using spacer elements.
Transformation of Carbinols by RuCl2(PPh3)3 and by Some Other Transition-Metal Catalysts
Pri-Bar, Ilan,Buchman, Ouri,Schumann, Hebert,Kroth, Heinz J.,Blum, Jochanan
, p. 4418 - 4428 (2007/10/02)
Several platinoid metal catalysts have been shown to promote reductive coupling, dehydration, disproportionation, and dehydrogenation of diarylcarbinols.Mechanistic studies were performed at 180-210 deg C with benzhydrol as substrate and RuCl2(PPh3)3 as catalyst.In aromatic hydrocarbon solvents the main process is reductive coupling.In this medium solvated RuCl2(PPh3)2 is suggested to be the active catalyst.In dimethyl sulfoxide the starting complex is transformed initially into RuCl2(PPh3)(Me2SO)2 and causes chiefly carbinol dehydrogenation.Ruthenium alkoxides are implied as common reaction intermediates in all four catalyses.Ruthenium hydrides are suggested to take part in the reductive coupling, disproportionation, and dehydrogenation processes.Some aliphatic and primary aromatic alcohols that do not react by themselves in the presence of RuCl2(PPh3)3 can both serve as active hydrogen donors and form crossover products in the presence of secondary and tertiary aromatic carbinols.
Preparation of novel keto-esters
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, (2008/06/13)
Novel keto-esters which are represented by the general formula STR1 wherein R1 represents methyl or benzyl, and X represents hydroxy, trityloxy, tosyloxy or halogen, and process for the preparation of said keto-esters.
