285991-67-5

Basic information

• Product Name: 4,6-dichloro-pyrimidine-5-carboxylic acid but-3-ynyl ester
• CAS NO: 285991-67-5
• Molecular Weight: 245.065
• Mol File: 285991-67-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4,6-dichloro-pyrimidine-5-carboxylic acid but-3-ynyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-pyrimidine-5-carboxylic acid but-3-ynyl ester(285991-67-5)
• EPA Substance Registry System: 4,6-dichloro-pyrimidine-5-carboxylic acid but-3-ynyl ester(285991-67-5)

Safety Data

• Hazardous Substances Data: 285991-67-5(Hazardous Substances Data)

Upstream product

• 927-74-2 3-Butyn-1-ol 
• 87600-97-3 4,6-dichloropyrimidine-5-carboxylic acid chloride 
• 5305-40-8 2,6-dichloro-pyrimidine carbaldehyde 

Relevant articles and documents

THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN

The Invention provides a compound of formula (I), (where A, X, Y, Z, R3, R4, R5, R6, m and n are disclosed herein) or a pharmaceutically acceptable salt thereof (the compound or pharmaceutically acceptable salt thereof being a "Piperazine Compound"); phar

A short total synthesis of cerpegin by intramolecular hetero Diels-Alder cycloaddition reaction of an acetylene tethered pyrimidine

The electron poor 4,6-dichloropyrimidine-5-carbaldehyde, which is readily available, is used as a starting material for the synthesis of fused 2-chloropyridines. Chlorination transforms the aldehyde into the corresponding acid chloride, which can be functionalized with acetylene tethers. Intramolecular hetero Diels-Alder reactions at elevated temperatures afford the fused pyridines in varying yield. This reaction sequence was applied to the total synthesis of cerpegin.