286008-56-8Relevant academic research and scientific papers
Novel Pyrimidine- And Triazine-Hepcidine Antagonists
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, (2015/09/30)
The present invention relates to new hepcidin antagonists, pharmaceutical compositions containing them and the use thereof as a drug, in particular for the treatment of iron metabolism disorders such as, in particular, iron deficiency diseases and anaemia, in particular anaemia associated with chronic inflammatory disease (ACD: anaemia of chronic disease and AI: anaemia of inflammation).
Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity
Musonda, Chitalu C.,Whitlock, Gavin A.,Witty, Michael J.,Brun, Reto,Kaiser, Marcel
scheme or table, p. 401 - 405 (2011/02/26)
A series of 2-pyridyl pyrimidines, reported inhibitors of Plasmodium falciparum methionine aminopeptidase 1b were synthesized and evaluated for their antiplasmodial activities. An analysis of physicochemical properties demonstrated a link between lipophil
