28606-61-3Relevant academic research and scientific papers
Daphniphyllum Alkaloids. 13. Asymmetric Total Synthesis of (-)-Secodaphniphylline
Heathcock, Clayton H.,Stafford, Jeffrey A.
, p. 2566 - 2574 (2007/10/02)
(-)-Secodaphniphylline (1) has been prepared by total synthesis.The early stages of the synthesis were an asymmetric version of the previously published synthesis of methyl homosecodaphniphyllate (2).The necessary chirality was secured by an asymmetric Mi
Asymmetric Total Synthesis of (-)-Secodaphniphylline
Stafford, Jeffrey A.,Heathcock, Clayton H.
, p. 5433 - 5434 (2007/10/02)
An asymmetric total synthesis of (-)-secodaphniphyllin (5) is described.The desired absolute stereochemistry is established in two stereoselective transformations - an asymmetric Michael reaction of amide 8 and an asymmetric reduction of ketone 14.
