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Fumarylacetoacetate is a chemical compound that plays a crucial role in the tyrosine catabolic pathway, acting as an intermediate in the conversion of tyrosine to fumarate and acetoacetate. It is metabolized by the enzyme fumarylacetoacetate hydrolase, which is essential for the breakdown and elimination of tyrosine in the body. Mutations in the gene encoding this enzyme can result in hereditary tyrosinemia type I, a rare genetic disorder that can cause liver and kidney damage if untreated.

28613-33-4

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28613-33-4 Usage

Uses

Used in Pharmaceutical Industry:
Fumarylacetoacetate is used as a therapeutic agent for the treatment of hereditary tyrosinemia type I. It helps in reducing the accumulation of toxic metabolites and alleviates the symptoms associated with the disorder.
Used in Research and Development:
Fumarylacetoacetate is used as a research tool in the study of tyrosine metabolism, enzyme function, and the molecular mechanisms underlying hereditary tyrosinemia type I. It aids in understanding the role of fumarylacetoacetate hydrolase and its implications in the development of therapeutic strategies for the disorder.
Used in Diagnostic Applications:
Fumarylacetoacetate can be used as a biomarker for the diagnosis of hereditary tyrosinemia type I. Elevated levels of fumarylacetoacetate in blood or urine samples can indicate the presence of the disorder, facilitating early detection and intervention.
Used in Drug Development:
Fumarylacetoacetate serves as a lead compound in the development of new drugs targeting the tyrosine catabolic pathway. Researchers can use its structure and properties to design and synthesize novel compounds with potential therapeutic benefits for hereditary tyrosinemia type I and other related conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 28613-33-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,6,1 and 3 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 28613-33:
(7*2)+(6*8)+(5*6)+(4*1)+(3*3)+(2*3)+(1*3)=114
114 % 10 = 4
So 28613-33-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/b2-1+

28613-33-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-fumarylacetoacetic acid

1.2 Other means of identification

Product number -
Other names fumarylacetoacetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28613-33-4 SDS

28613-33-4Downstream Products

28613-33-4Relevant academic research and scientific papers

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