28623-31-6

Upstream product

• 822-39-9 2-chloro-1,3,2-dioxaphospholan 
• 108-18-9 diisopropylamine 

Downstream Products

• 40928-00-5 isopropyl ethylene phosphite 
• 108-18-9 diisopropylamine 
• 220995-86-8 2-N-Benzylimino-2-diisopropyl-1,3,2-λ⁵-dioxaphospholane 
• 220995-84-6 2-Diisopropylamino-2-N-phenylimino-1,2,3-λ⁵-dioxaphospholane 
• 220995-96-0 2-Diisopropyl-2-N'-(4-nitrobenzyl)imino-1,3,2-λ⁵-dioxaphospholane 

Relevant academic research and scientific papers

Phosphoric acid phaseomannite class compound and its preparation method and application (by machine translation)

The invention discloses a phaseomannite class phosphate compound, phosphoric acid phaseomannite class compound preparation method, and these phosphoric acid phaseomannite class compounds in the preparation of an anti-tumor drug. The use of non-small cell lung cancer cells to the compounds of this invention to inhibit the growth of tumor cells in active testing, that the compounds of this invention have high inhibition of tumor cell growth activity, some of the compound inhibiting activity even with cisplatin active quite, which indicates that the compounds of this invention have good cell penetrability and phosphorus esterase stability, can be used for the development of anti-tumor medicament. (by machine translation)

Imide-amide rearrangement of cyclic phosphorimidates: A mechanistic study

Studies aimed at the development of new synthetic pathways for the preparation of chiral cyclic oxaza and diaza phosphoramides suitable for use in asymmetric chemistry led us to the investigation of the imide-amide rearrangement of cyclic phosphorimidates

Preparation of phospholipid analogues using the phosphoramidite route

The phosphoramidite route has been used to prepare phospholipid analogues possessing biocompatible properties and the monomer 2-(methacryloyIoxy)ethylphosphorylcholine, utilised in the preparation of biocompatible polymers. Modifications to established methodology include, as an alternative to the thermally unstable tetrazole, the use of 4,5-dichloroimidazole as an acid catalyst for preparing phosphite esters from the corresponding phosphoramidites, and the use of trimethylamine N-oxide as oxidant for the conversion of the phosphite esters into the corresponding phosphates. The Royal Society of Chemistry 2000.

Conformation and Stereodynamics of 2-Dialkylamino-1,3-dioxa- and 3-Methyl-1,3-oxaza-2-phospholanes. A Carbon-13 Nuclear Magnetic Resonance and Theoratical MNDO Investigation.

Rotation around the exocyclic P-NR2 bond in the title compounds (R = Me, Et, and i-Pr) has been frozen on the 13C n.m.r. time-scale at -100 to -150 deg C.The exocyclic PNC coupling constants confirm that the preferred conformation has one NR group eclipsing the phosphorus lone pair and the other lying over the face of the ring; this geometry is also supported by MNDO SCF MO calculations.The P-NR2 rotational barriers, which lie in the range 6.0-9.2 kcal/mol, increase in the sequence 1,3-dioxa- 1,3-oxaza- 1,3-diazaphospholane and also with increasing size of the NR group.MNDO calculations of the barrier height reproduce the former sequence.The cyclic POC and PNC coupling constants are discussed in relation to the ring conformation, and some 15N n.m.r. data are reported.