286368-53-4

Basic information

• Product Name: 5-(2-phenoxy)phenyl-1,3,4-oxadiazole-2-yl 4-dimethylaminobenzoate
• Synonyms: 5-(2-phenoxy)phenyl-1,3,4-oxadiazole-2-yl 4-dimethylaminobenzoate
• CAS NO: 286368-53-4
• Molecular Weight: 401.422
• Mol File: 286368-53-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(2-phenoxy)phenyl-1,3,4-oxadiazole-2-yl 4-dimethylaminobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-phenoxy)phenyl-1,3,4-oxadiazole-2-yl 4-dimethylaminobenzoate(286368-53-4)
• EPA Substance Registry System: 5-(2-phenoxy)phenyl-1,3,4-oxadiazole-2-yl 4-dimethylaminobenzoate(286368-53-4)

Safety Data

• Hazardous Substances Data: 286368-53-4(Hazardous Substances Data)

Upstream product

• 619-84-1 p-N,N-dimethylaminobenzoic acid 

Relevant articles and documents

One-step, no-carrier-added, synthesis of a 18F-Labelled benzodiazepine receptor ligand

5-(2-Phenoxy)phenyl-1,3,4-oxadiazole-2-yl-4-fluorobenzoate, a non-classical benzodiazepine receptor ligand, has shown anticonvulsant activity against pentylenetetrazole-induced convulsion. In order to perform biological studies, we decided to label the compound with positron-emitting fluorine-18 (t( 1/2 ) = 109.7 min). The latter compound was prepared in no-carrier-added form from [18F]fluoride and 5-(2-phenoxy)phenyl-1,3,4-oxadiazole-2-yl-4-N,N,N-trimethylanilinium triflate in one step. The best results were obtained using Kryptofix2.2.2/[18F]fluoride with dimethylsulfoxide as the solvent at 90°C. Column chromatography afforded the desired compound in 15 min in an overall radiochemical yield of 70-75% corrected to the end of radionuclide production with a specific radioactivity of about 3000 Ci/mmol and a radiochemical purity of more than 95% and high chemical purity.