286376-14-5

Upstream product

• 18887-52-0 2,2'-(ethyne-1,2-diyl)dibenzaldehyde 
• 10602-08-1 2-ethynylbenzyl alcohol 
• 38846-64-9 2-ethynylbenzaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 
• 18887-53-1 2-<2-<2-(Hydroxymethyl)phenyl>ethynyl>benzaldehyde 
• 18887-51-9 2,2'-Bis-acetoxymethyl-diphenylacetylen 
• 18887-49-5 2-[2-(2-hydroxymethylphenyl)-1-ethynyl]phenylmethanol 

Relevant academic research and scientific papers

Regio- and stereoselective intramolecular hydroalkoxylation of aromatic alkynols: an access to dihydroisobenzofurans under transition-metal-free conditions

An efficient, transition-metal-free method to synthesize dihydroisobenzofuran derivatives via intramolecular hydroalkoxylation of aromatic alkynols with the promotion of cesium carbonate has been developed. The reaction proceeds regioselectively with exclusive formation of 5-exo-dig product, and only Z-isomer of the new generated double bond is observed. This new protocol features with milder reaction conditions, more convenient operation and satisfactory selectivities.

Synthesis of aromatic triynes as precursors to helicene derivatives

A general and versatile synthetic approach to a broad series of aromatic triynes as precursors to helicene derivatives has been developed. Employing a set of simple tools, triynes comprising the (phenylethynyl)benzene, 1-(phenylethynyl)naphthalene, and 1-(1-naphthylethynyl)-naphthalene moiety have been prepared in good to excellent yields throughout the whole reaction sequence. The methodology allows constructing various types of a junction between the central diarylacetylene moiety and the attached acetylene units to get the target triynes of general formula R-C≡C-CH2-X-CH2-Ar-C≡C-Ar-CH 2-X-CH2-C≡C-R or R-C≡C-CH2CH2-Ar-C=C-Ar-CH2CH 2-C≡C-R (R = H, CH3, TMS, or TIPS; X = O, NTs, or C(CO2CH3)2; Ar/Ar = 2-phenylene or 2-naphthylene).