286386-34-3Relevant academic research and scientific papers
Copper(I) complexes with N,O-donor schiff base ligands related to intermediate forms of the TPQ cofactor in amine oxidases
Sixt, Torsten,Kaim, Wolfgang
, p. 762 - 768 (2000)
Neutral complexes (PPh3)2Cu(L) were obtained from (PPh3)2Cu(NO3) and the deprotonated forms of the three Schiff base ligands 2-(benzylideneimino)phenol (BimOH), 4-(benzylideneimino)resorcinol (Bim(OH)2) and N-(2,4-dihydroxy-5-isopropylphenyl)acetamide (DipaH3). The ligands were designed to model aminated intermediate forms of the topaquinone (TPQ) cofactor in the enzymatic cycle of copper-dependent amine oxidases. The ligands L are coordinated to the metal centers through imine-N and phenolate-O donor atoms to form five-membered chelate rings, in contrast to the six-membered chelate rings of salen-type Schiff base ligands. Compound (Bim(OH)O)Cu(PPh3)2·0.5CH3OH was structurally analyzed, it exhibits intramolecular aryl-aryl interactions between the ligands and intermolecular hydrogen bonds involving the free phenolic hydroxyl substituent, the coordinated phenolate oxygen atom and the methanol solvate molecule. (C) 2000 Elsevier Science S.A.
