28639-18-1Relevant academic research and scientific papers
ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT
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, (2008/06/13)
The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the de
ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT
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Page/Page column 55, (2008/06/13)
The invention relates to aryl-substituted polycyclic amines of formula I, particularly bicyclic amines, and the physiologically acceptable salts and physiologically functional derivatives thereof, the symbols and radicals being defined as indicated in the description.
Stereoselectivity in the Photoinduced Electron Transfer (PET) promoted intramolecular cyclisations of 1-alkenyl-2-silyl-piperidines and -pyrrolidines: Rapid construction of 1-azabicyclo[m.n.0] alkanes and stereoselective synthesis of (±)-isoretronecanol and (±)-epilupinine
Pandey, Ganesh,Reddy, Gottimukkula Devi,Chakrabarti, Debasish
, p. 219 - 224 (2007/10/03)
PET promoted cyclisations of 1-alkenyl-2-silyl-pyrrolidines and -piperidines 9a-d to 1-aza-bicyclo[m.n.0]alkanes have been found to be stereoselective. The five-membered ring formation gives predominantly cis products while six-membered rings are trans. Application of such cyclisations to the synthesis of (±)-isoretronecanol 22a, (±)-epilupinine 29 and related alkaloids has been demonstrated. Copyright 1996 by the Royal Society of Chemistry.
Sequential two-electron oxidation of α,α′-disilylmethylamines to generate non-stabilized azomethine ylide: An ideal approach for the construction of substituted and fused pyrrolidine ring systems
Pandey, Ganesh,Lakshmaiah,Gadre, Smita R.
, p. 91 - 98 (2007/10/03)
α,α′-Di(trimethylsilylmethyl)amines undergo sequential double desilylation processes, by two-electron oxidation initiated either by photoinduced electron transfer (PET) or Ag(I)F, to produce non-stabilized azomethine ylides efficiently which upon trapping with appropriate dipolarophiles give the corresponding pyrrolidines. Application of this strategy to cyclic analogue for the rapid construction of biologically important 1-azabicyclo[m,3.0]alkane framework is discussed.
A NEW ROUTE TO HEXAHYDROPYRROLIZINES DERIVATIVES VIA NONSTABILIZED YLIDE GENERATED FROM N-METHYLPYRROLIDINE N-OXIDE
Chastanet, Jacqueline,Roussi, Georges
, p. 653 - 659 (2007/10/02)
N-Methylpyrrolidine N-oxide treated with lithium diisopropylamide in the presence of various olefins, leads to the corresponding hexahydropyrrolizines(6) via the ylide intermediate (5).
USE OF INTRAMOLECULAR AZA-WITTIG REACTION FOR THE ACCESS TO 2-CYCLOPROPYL CYCLIC IMINES WHICH ARE KEY INTERMEDIATES IN THE SYNTHESIS OF BICYCLIC ALCALOIDS
Vaultier, M.,Lambert, P. H.,Carrie, R.
, p. 449 - 456 (2007/10/02)
A simple access to functionalized 2-cyclopropyl cyclic imines via an intramolecular aza-Wittig reaction is described.The thermal rearrangement of these compounds in the presence of trace amounts of ammonium chloride leads to bicyclic (x=3,4,5) vinylogous urethanes and amides in good yields.
