286409-19-6

Upstream product

• 286409-18-5 (+)-(3R,4R,6S)-3-hydroxy-6-hydroxymethyl-4-methoxy-1,7-octadiene 
• 221015-48-1 (1R,5R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,8-dioxa-bicyclo[3.2.1]oct-3-en-2-one 
• 286409-17-4 (3S,5R,6R)-5-Methoxy-3,6-divinyl-tetrahydro-pyran-2-ol 
• 286409-16-3 (+)-(1S,2R,4S,5R,7S)-7-iodomethyl-2-methoxy-4-vinyl-6,8-dioxabicyclo[3.2.1]octane 
• 286409-14-1 (+)-(1S,2R,4S,5R,7S)-7-hydroxymethyl-2-methoxy-4-vinyl-6,8-dioxabicyclo[3.2.1]octane 
• 286409-13-0 (+)-(1S,2R,4S,5R,7S)-7-tert-butyldimethylsiloxymethyl-2-methoxy-4-vinyl-6,8-dioxabicyclo[3.2.1]octane 
• 286409-11-8 (+)-(1R,4S,5R,7S)-7-tert-butyldimethylsiloxymethyl-4-vinyl-6,8-dioxabicyclo[3.2.1]oct-2-one 
• 286409-15-2 Methanesulfonic acid (1S,2R,4S,5R,7S)-2-methoxy-4-vinyl-6,8-dioxa-bicyclo[3.2.1]oct-7-ylmethyl ester 

Downstream Products

• 109466-73-1 (-)-(1R,2R,4R)-4-hydroxymethyl-2-methoxycyclohexan-1-ol 

Relevant academic research and scientific papers

Ring-closing metathesis protocol for a diastereocontrolled preparation of the C28-C34 segment of FK-506

A new synthesis of the C28-C34 segment of FK-506 has been developed using a chiral building block having a 6,8-dioxabicyclo[3.2.1]octane framework by employing a ring-closing metathesis reaction as the key step. Copyright (C) 2000 Elsevier Science Ltd.