28657-53-6

Upstream product

• 29312-77-4 acide α-methyl β-p-methoxy-benzoyl lactique 
• 50-00-0 formaldehyd 
• 1027102-72-2 4-diethoxyphosphoryl-6-(4-methoxyphenyl)-pyridazin-3(2H)-one 
• 5717-16-8 2-methyl-4-oxo-4-(4-methoxyphenyl)-butyric acid 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 2170-03-8 itaconic acid anhydride 
• 845961-30-0 methyl 4-(4-methoxyphenyl)-2-methylene-4-oxobutanoate 
• 28657-46-7 methyl-4 hydroxy-4 (p-methoxy phenyl)-6 pyridazinone-3 

Downstream Products

• 118270-10-3 C₁₁H₁₀N₂O₂ 
• 105538-32-7 6-Amino-1-(3-ethoxycarbonyl-propyl)-3-(4-methoxy-phenyl)-5-methyl-pyridazin-1-ium; bromide 
• 105537-83-5 6-Amino-1-(3-carboxy-propyl)-3-(4-methoxy-phenyl)-5-methyl-pyridazin-1-ium; bromide 
• 86663-21-0 6-(4-Methoxy-phenyl)-4-methyl-pyridazin-3-ylamine 
• 60855-55-2 3-hydrazino-6-(4-methoxy-phenyl)-4-methyl-pyridazine 
• 118269-93-5 [6-(4-Methoxy-phenyl)-4-methyl-pyridazin-3-yl]-(2-morpholin-4-yl-ethyl)-amine; hydrochloride 
• 86663-17-4 3-<(β-Morpholinoethyl)amino>-4-methyl-6-(4-hydroxyphenyl)pyridazine dihydrobromide 
• 28734-31-8 3-chloro-6-(4-methoxy-phenyl)-4-methyl-pyridazine 

Relevant academic research and scientific papers

Identification of pyridazin-3-one derivatives as potent, selective histamine H3 receptor inverse agonists with robust wake activity

H3R structure-activity relationships on a novel class of pyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone core, central phenyl ring and linker led to the identification of molecules wi

New, simple and versatile synthesis of 4,6-disubstituted pyridazin-3(2H)-ones

A simple, two-step synthesis of 4,6-disubstituted pyridazin-3(2H)-ones starting from 2-diethoxyphosphoryl-4-oxoalkanoates and hydrazines is described. The intermediate 4-diethoxyphosphoryl-4,5-dihydropyridazin-3(2H)-ones obtained in this way are used in a

Pyridizinone derivatives

The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.

Synthesis and hypotensive activity of some 6-(substituted aryl)-4-methyl-2,3-dihydropyridazin-3-ones

6-(Substituted aryl)-4-methyl-2,3-dihydropyridazin-3-ones are synthesized by cyclisation of appropriate β-(substituted aroyl)-2-methylene propionate with hydrazine hydrate in the presence of sodium acetate. The title compounds are tested for hypotensive activity, non-invasively, by tail-cuff method and are found to possess significant hypotensive activity in normotensive rats.

3-Aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities

Minaprine [3[(β-morpholinoethyl)amino]4-methyl-6-phenylpyridazine dihydrochloride] is active in most animal models of depression and exhibits in vivo a dual dopaminomimetic and serotoninomimetic activity profile. In an attempt to dissociate these two effe

Obtention selective d'hydroxy-4 pyridazinones-3 et de pyridazones-3. Etude des modalites de la cyclocondensation des acides β-acyl lactiques avec l'hydrazine

The authors reinvestigate the cyclocondensation reaction of β-acyl lactic acids with hydrazine and propose operating conditions allowing a selective and quantitative access either to 4-hydroxypyridazin-3 ones or, directly, to the corresponding pyridazin-3- ones.