28657-79-6 Usage
Uses
Used in Pharmaceutical Industry:
1-Ethyl-1,4-dihydro-4-oxo[1,3]dioxolo[4,5-g]cinnoline-3-carbonitrile is used as an intermediate in the synthesis of Cinoxacin (C475700), an antibacterial quinolone. It is particularly effective in the treatment of urinary tract infections due to its potent antimicrobial properties and ability to target a wide range of bacteria.
1-ethyl-1,4-dihydro-4-oxo[1,3]dioxolo[4,5-g]cinnoline-3-carbonitrile's role in the pharmaceutical industry is crucial, as it contributes to the development of new drugs and therapies that can help combat bacterial infections and improve patient outcomes. Its unique chemical structure allows for further modification and optimization, potentially leading to the discovery of more effective and safer antibacterial agents.
Check Digit Verification of cas no
The CAS Registry Mumber 28657-79-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,6,5 and 7 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 28657-79:
(7*2)+(6*8)+(5*6)+(4*5)+(3*7)+(2*7)+(1*9)=156
156 % 10 = 6
So 28657-79-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H9N3O3/c1-2-15-9-4-11-10(17-6-18-11)3-7(9)12(16)8(5-13)14-15/h3-4H,2,6H2,1H3
28657-79-6Relevant academic research and scientific papers
Process for the preparation of 1-alkyl-3-carboxy-4-cinnolones
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, (2008/06/13)
A process for the preparation of 1-alkyl-3-carboxy-4-cinnolones of formula I STR1 wherein R and R1 are electron donor groups and R3 is an alkyl group, starting from an amine of formula II STR2 which is subjected to the following transformations; (1) diazotation; (2) coupling with a cyanoacetic ester; (3) alkylation of the arylhydrazone obtained in (2); (4) hydrolysis of the ester and conversion into acyl chloride; (5) intramolecular cyclization; (6) hydrolysis of the nitrile residue.
A process for the preparation of 1-alkyl-3-carboxy-4-cinnolones.
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, (2008/06/13)
A process for the preparation of 1-alkyl-3-car-boxy-4-cinnolones of formula I wherein R and R1 are electron donor groups and R3 is an alkyl group,starting from an amine of formula II which is subjected to the following transformations; 1) diazotation; 2) coupling with a cyanoacetic ester; 3) alkylation of the arylhydrazone obtained in 2); 4) hydrolysis of the ester and conversion into acyl chloride; 5) intramolecular cyclization; 6) hydrolysis of the nitrile residue.
