28666-14-0Relevant academic research and scientific papers
One-pot synthesis of 3-aminofurans using a simple and efficient recyclable CuI/[bmim]PF6system
Balaboina, Ramesh,Guguloth, Veeranna,Thirukovela, Narasimha Swamy,Vadde, Ravinder
supporting information, p. 7438 - 7445 (2021/09/08)
A one-pot three-component reaction of several 2-ketoaldehydes, secondary amines and terminal alkynes to access 3-aminofurans proceeded well in [bmim][PF6] using a simple and cheap CuI catalyst. The resultant 3-aminofuran products were easily isolated using diethyl ether and the CuI/[bmim][PF6] system was reused six times with a slight decrease in the activity.
Gold(III)-catalyzed three-component coupling reaction (TCC) selective toward furans
Li, Jian,Liu, Li,Ding, Dong,Sun, Jiangtao,Ji, Yangxuan,Dong, Jialing
supporting information, p. 2884 - 2887 (2013/07/19)
An efficient three-component coupling reaction toward a variety of furan derivatives has been developed. This cascade transformation proceeds via the gold-catalyzed coupling reaction of phenylglyoxal derivatives, secondary amines, and terminal alkynes, under the reaction conditions, that undergoes cyclization into the furan core.
The Willgerodt-Kindler Reactions. 6. Isomerization of the Carbonyl Group in Alkanones and Cycloalkanones
Carmack, Marvin,Behforouz, Mohammad,Berchtold, Glenn A.,Berkowitz, Samuel M.,Wiesler, Donald,Barone, Ralph
, p. 1305 - 1318 (2007/10/02)
The most unusual feature of the Willgerodt-Kindler Reactions is the facile isomerization of the carbonyl function along a chain of unbranched methylene groups, or around a cycloaliphatic ring containing several connected methylene groups.We have demonstrated that the first step in the Kindler process is the formation of enamines by reaction of the carbonyl function with secondary aliphatic amines, followed by reaction of the enamine with certain sulfur-amine catalysts to form reactive heterocyclic sulfur intermediates that facilitate the elimination-readdition of the amines reversibly along the chain.It was shown that compounds of the type R2N-S-S-NR2 are effective catalysts but not compounds of the type R2N-S-NR2.Some cyclohexanone derivatives undergo aromatization, with anomalous results in certain cases.
