28718-76-5

Upstream product

• 4231-16-7 1-(p-nitrophenyl)-2-nitro-1-propene 
• 1761-61-1 5-bromosalicyclaldehyde 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 92161-14-3 5-Brom-2-<4-nitro-benzyloxy>benzaldehyd 
• 636-98-6 p-nitrobenzene iodide 
• 1060684-44-7 4-bromo-O-triisopropylsilyl-2-iodophenol 
• 78-27-3 1-Ethynylcyclohexan-1-ol 

Downstream Products

• 1246471-04-4 C₁₄H₁₀N₂O₃ 
• 503300-04-7 5-iodo-2-(4-methylaminophenyl)benzofuran 
• 28718-77-6 5-bromo-2-(4-aminophenyl)benzofuran 
• 1246471-53-3 C₂₀H₂₀BNO₅ 

Relevant academic research and scientific papers

Catalyst-Free Synthesis of Benzofuran Derivatives from Cascade Reactions between Nitroepoxides and Salicylaldehydes

Different benzofuran derivatives are synthesized via a catalyst-free reaction between nitroepoxides and salicylaldehydes. In the employed methodology, K2CO3 and DMF have been used at 110 °C, and the reactions were completed after 12 h in 33-84% yields. Th

Development of Radioiodinated Benzofuran Derivatives for in Vivo Imaging of Prion Deposits in the Brain

Prion diseases are fatal neurodegenerative disorders associated with the deposition of abnormal prion protein aggregates (PrPSc) in the brain tissue. Here, we report the development of 125I-labeled iodobenzofuran (IBF) derivatives as

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Development of a one-pot sequential Sonogashira coupling for the synthesis of benzofurans

An efficient one-pot protocol was developed for the construction of the benzofuran system from aryl halides and protected iodophenols using carbinol-based acetylene sources. The sequence includes alternating palladium-catalyzed Sonogashira couplings and deprotection steps concluded by a ring closure. The developed one-pot procedure was compared with the stepwise approach and its efficiency was also demonstrated by the total synthesis of vignafuran, a benzofuran natural product.