287196-66-1 Usage
Description
(2-chlorophenyl)(1H-imidazol-2-yl)methanone, also known as Clomethiazole, is a chemical compound belonging to the imidazole class. It is a sedative and hypnotic drug that was once used for its anxiolytic and anticonvulsant properties. Clomethiazole exerts its effects on the central nervous system, making it a compound of interest in pharmacological and medical research despite its discontinued use due to potential for abuse, dependence, and side effects.
Uses
Used in Pharmaceutical Industry:
(2-chlorophenyl)(1H-imidazol-2-yl)methanone was utilized as a sedative and hypnotic agent for its ability to calm and induce sleep in patients. It was particularly employed in the treatment of alcohol withdrawal to manage symptoms and prevent the onset of delirium tremens.
Used in Research and Study:
Despite its discontinued clinical use, (2-chlorophenyl)(1H-imidazol-2-yl)methanone continues to be a subject of interest in the fields of pharmacology and medicine. Its effects on the central nervous system and its historical applications provide valuable insights for the development of new therapeutic agents and understanding of related drug mechanisms.
Check Digit Verification of cas no
The CAS Registry Mumber 287196-66-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,1,9 and 6 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 287196-66:
(8*2)+(7*8)+(6*7)+(5*1)+(4*9)+(3*6)+(2*6)+(1*6)=191
191 % 10 = 1
So 287196-66-1 is a valid CAS Registry Number.
287196-66-1Relevant articles and documents
Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors
Guo, Jing,Zhao, Fan,Yin, Wenbo,Zhu, Mingyue,Hao, Chenzhou,Pang, Yu,Wu, Tianxiao,Wang, Jian,Zhao, Dongmei,Li, Haitao,Cheng, Maosheng
, p. 197 - 209 (2018)
We have previously described the identification of indolin-2-one-5-carboxamides as potent PAK4 inhibitors. This study expands the structure-activity relationships on our original series by presenting several modifications in the lead compounds, 2 and 3. A series of novel derivatives was designed, synthesized, and evaluated in biochemical and cellular assay. Most of this series displayed nanomolar biochemical activity and potent antiproliferative activity against A549 and HCT116 cells. The representative compound 10a exhibited excellent enzyme inhibition (PAK4 IC50 = 25 nM) and cellular potency (A549 IC50 = 0.58 μM, HCT116 IC50 = 0.095 μM). An X-ray structure of compound 10a bound to PAK4 was obtained. Crystallographic analysis confirmed predictions from molecular modeling and helped refine SAR results. In addition, Compound 10a displayed focused multi-targeted kinase inhibition, good calculated drug-likeness properties. Further profiling of compound 10a revealed it showed weak inhibitory activity against various isoforms of human cytochrome P450.
