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(2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(2-bromophenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate is a complex organic compound with a molecular formula of C21H25BrO9. It is a chiral molecule, meaning it has a non-superimposable mirror image, and it possesses five stereocenters, which are carbon atoms with four different substituents. The compound features a tetrahydro-2H-pyran ring, which is a cyclic structure with four carbon atoms and one oxygen atom. Additionally, it has three acetate groups attached to the 3, 4, and 5 positions of the pyran ring, and a 2-bromophenoxy group at the 6 position. This chemical structure is significant in the field of organic chemistry, particularly in the synthesis of complex molecules and pharmaceuticals, due to its unique stereochemistry and functional groups.

2872-69-7

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2872-69-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2872-69-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,7 and 2 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2872-69:
(6*2)+(5*8)+(4*7)+(3*2)+(2*6)+(1*9)=107
107 % 10 = 7
So 2872-69-7 is a valid CAS Registry Number.

2872-69-7Downstream Products

2872-69-7Relevant academic research and scientific papers

Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design

Maddirala, Amarendar Reddy,Klein, Roger,Pinkner, Jerome S.,Kalas, Vasilios,Hultgren, Scott J.,Janetka, James W.

, p. 467 - 479 (2019)

The F9/Yde/Fml pilus, tipped with the FmlH adhesin, has been shown to provide uropathogenic Escherichia coli (UPEC) a fitness advantage in urinary tract infections (UTIs). Here, we used X-ray structure guided design to optimize our previously described ortho-biphenyl Gal and GalNAc FmlH antagonists such as compound 1 by replacing the carboxylate with a sulfonamide as in 50. Other groups which can accept H-bonds were also tolerated. We pursued further modifications to the biphenyl aglycone resulting in significantly improved activity. Two of the most potent compounds, 86 (IC50 = 0.051 μM) and 90 (IC50 = 0.034 μM), exhibited excellent metabolic stability in mouse plasma and liver microsomes but showed only limited oral bioavailability (50 for 6 h. These new FmlH antagonists represent new antivirulence drugs for UTIs.

COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS

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Paragraph 0143; 0145, (2019/05/30)

The present invention is directed to various compounds, compositions, and methods for treating bacterial infections such as urinary tract infections.

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